Journal ArticleDOI
The role of miRNA in inflammation and autoimmunity
Ram P. Singh,Israel Massachi,Sudhir Manickavel,Satendra Singh,Nagesh Rao,Sascha Hasan,Deborah K. Mc Curdy,Sherven Sharma,David T.W. Wong,Bevra H. Hahn,Hamida Rehimi +10 more
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TLDR
This review discusses how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets and focused the influence of gender and sex hormones on miRNA.About:
This article is published in Autoimmunity Reviews.The article was published on 2013-10-01. It has received 264 citations till now.read more
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MicroRNAs as regulatory elements in immune system logic
Arnav Mehta,David Baltimore +1 more
TL;DR: The mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output are discussed, first at the level of haematic stem cells, then in innate and adaptive immune cells, and the pathological consequences of dysregulation of these mi RNAs are discussed.
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Long noncoding RNAs: Novel insights into hepatocelluar carcinoma
TL;DR: The regulation and functional role of lncRNAs in HCC is discussed and the potential of lNCRNAs as prospective novel therapeutic targets in H CC is evaluated.
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Sex-based differences in autoimmune diseases.
Elena Ortona,Marina Pierdominici,Angela Maselli,Caterina Veroni,Francesca Aloisi,Yehuda Shoenfeld +5 more
TL;DR: Possible mechanisms for sex specific differences in autoimmunity with a special focus on three paradigmatic diseases: systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis are discussed.
Journal ArticleDOI
Emerging role of long noncoding RNAs in autoimmune diseases.
TL;DR: This work focuses on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression in autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, multiple sclerosis, autoimmune thyroid disease, psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease.
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Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors.
TL;DR: Insight is provided into the development of non-viral synthetic miRNA vectors and the promise of miRNA-based anticancer therapies, including therapeutic applications of miRNAs, challenges of vector design to overcome the delivery obstacles, and the developmentof miRNA delivery systems for cancer therapy.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
TL;DR: A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.
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Multiple Sclerosis — The Plaque and Its Pathogenesis
TL;DR: This review focuses on the current knowledge of the pathogenesis of the inflammatory and neurodegenerative elements of the multiple sclerosis plaque.
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miR-21-mediated tumor growth
TL;DR: The results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target.
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Sex differences in autoimmune disease
TL;DR: A new interest in understanding the biology of this difference as well as funding opportunities have focused attention on research priorities in sex differences.