The role of mRNA m 6 A methylation in the nervous system
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TLDR
The research progress and related mechanisms of the role of mRNA m6A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma are reviewed.Abstract:
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m6A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m6A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m6A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m6A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.read more
Citations
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The role of m6A modification in the biological functions and diseases.
Xiulin Jiang,Xiulin Jiang,Baiyang Liu,Baiyang Liu,Zhi Nie,Zhi Nie,Zhi Nie,Lincan Duan,Qiuxia Xiong,Zhixian Jin,Cui-Ping Yang,Yongbin Chen,Yongbin Chen +12 more
TL;DR: In this paper, the authors discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems.
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Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse Tissues
Jun’e Liu,Kai Li,Jia-Bin Cai,Jia-Bin Cai,Mingchang Zhang,Xiaoting Zhang,Xushen Xiong,Haowei Meng,Xizhan Xu,Zhibin Huang,Jinying Peng,Jia Fan,Jia Fan,Chengqi Yi +13 more
TL;DR: The m6A and m6Am methylome is reported through profiling of 43 human and 16 mouse tissues and demonstrates strongest tissue specificity for the brain tissues and cross-species analysis revealed that species rather than tissue type is the primary determinant of methylation.
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The role of N 6 -methyladenosine (m 6 A) modification in the regulation of circRNAs
TL;DR: The role of m6A modification in the regulation and function of circRNAs is summarized and the potential applications and possible future directions in the field are discussed.
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The mechanism of m 6 A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene
Shuiping Liu,Qiujie Li,Guohua Li,Qin Zhang,Lvjia Zhuo,Xuemeng Han,Mingming Zhang,Xiaying Chen,Ting Pan,Lili Yan,Ting Jin,Jianjun Wang,Qun Lv,Xinbing Sui,Tian Xie +14 more
TL;DR: The mechanism of METTL3-mediated autophagy in reversing gefitinib resistance of NSCLC cells by β-elemene is unveiled, which shed light on providing potential molecular-therapy target and clinical-treatment method in NSclC patients with gefitsinib resistant cells.
Journal ArticleDOI
Function and evolution of RNA N6-methyladenosine modification.
TL;DR: Accumulating evidence shows that m6A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses.
References
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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
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Kate D. Meyer,Yogesh Saletore,Paul Zumbo,Olivier Elemento,Christopher E. Mason,Samie R. Jaffrey +5 more
TL;DR: A method is presented for transcriptome-wide m(6)A localization, which combines m( 6)A-specific methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-Seq) and reveals insights into the epigenetic regulation of the mammalian transcriptome.
Journal ArticleDOI
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
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TL;DR: FTO exhibits efficient oxidative demethylation activity of abundant N6-methyladenosine (m6A) residues in RNA in vitro, and it is shown that FTO partially colocalizes with nuclear speckles, supporting m6A in nuclear RNA as a physiological substrate of FTO.
Journal ArticleDOI
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Guanqun Zheng,John Arne Dahl,Yamei Niu,Peter Fedorcsak,Chun-Min Huang,Charles J. Li,Cathrine Broberg Vågbø,Yue Shi,Yue Shi,Wen-Ling Wang,Wen-Ling Wang,Shuhui Song,Zhike Lu,Ralph P. G. Bosmans,Qing Dai,Ya-Juan Hao,Ya-Juan Hao,Xin Yang,Xin Yang,Wenming Zhao,Wei-Min Tong,Xiu-Jie Wang,Florian Bogdan,Kari Furu,Ye Fu,Guifang Jia,Xu Zhao,Xu Zhao,Jun Liu,Hans E. Krokan,Arne Klungland,Yun-Gui Yang,Yun-Gui Yang,Chuan He +33 more
TL;DR: The discovery of ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo strongly suggests that the reversible m( 6)A modification has fundamental and broad functions in mammalian cells.
Journal ArticleDOI
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Xiao Wang,Xiao Wang,Boxuan Simen Zhao,Boxuan Simen Zhao,Ian A Roundtree,Ian A Roundtree,Zhike Lu,Zhike Lu,Dali Han,Dali Han,Honghui Ma,Honghui Ma,Xiaocheng Weng,Xiaocheng Weng,Kai Chen,Kai Chen,Hailing Shi,Hailing Shi,Chuan He,Chuan He +19 more
TL;DR: In a unified mechanism of m(6)A-based regulation in the cytoplasm, YTHDF2-mediated degradation controls the lifetime of target transcripts, whereasYTHDF1-mediated translation promotion increases translation efficiency, ensuring effective protein production from dynamic transcripts that are marked by m( 6)A.
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