The role of myelin and oligodendrocytes in axonal energy metabolism.
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806 citations
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...A similar intercellular trafficking of lactate across gap junctions necessary for axonal function has been shown to occur between astrocytes and oligodendrocytes (Fünfschilling et al., 2012; Saab et al., 2013)....
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595 citations
538 citations
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...However, it remains unclear whether on-board energy production by Neuron 84, October 22, 2014 ª2014 Elsevier Inc. 301 glycolysis is required for axonal transport in vivo, as the energetic lives of glia and neurons are intimately linked (Saab et al., 2013)....
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520 citations
Cites background from "The role of myelin and oligodendroc..."
...Here, in addition to their well-known role in saltatory conduction, oligodendrocytes serve as a source of energy-rich metabolites (lactate) for the axonal compartment, thereby supporting axonal ATP production and energy homeostasis (Beirowski, 2013; Saab et al., 2013)....
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483 citations
Cites background from "The role of myelin and oligodendroc..."
...(From Saab et al. 2013; modified, with permission, from Elsevier Limited # 2013.)...
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References
3,903 citations
"The role of myelin and oligodendroc..." refers background in this paper
...Axonal degeneration in MS has been intensely studied [33,34], but here the causal relationship of inflammation, demyelination, and axon loss has remained unclear [35]....
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2,521 citations
"The role of myelin and oligodendroc..." refers background in this paper
...The latter, referred to as the ‘lactate shuttle’ [23], has been hypothesized to constantly adjust synaptic glucose utilization and energy consumption to glutamatergic neurotransmission [24,25], which is also important to memory formation [26 ]....
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1,560 citations
"The role of myelin and oligodendroc..." refers background in this paper
...Axonal degeneration in MS has been intensely studied [33,34], but here the causal relationship of inflammation, demyelination, and axon loss has remained unclear [35]....
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1,532 citations
"The role of myelin and oligodendroc..." refers background in this paper
...Axonal degeneration in MS has been intensely studied [33,34], but here the causal relationship of inflammation, demyelination, and axon loss has remained unclear [35]....
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1,298 citations
"The role of myelin and oligodendroc..." refers background in this paper
...[7 ])....
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...Glycolytic oligodendrocytes support the axonal energy metabolism Two recent papers have shed new light on the role of oligodendrocytes in the adult brain, and have identified at least one axonal support mechanism [6 ,7 ]....
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...It caused a late-onset pathology with axonal spheroids and degeneration in the brain and the spinal cord [7 ], virtually identical to the axonopathy of Plp1 null mutant mice [4] discussed above....
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...Importantly, MCT1 blockage could be rescued by adding free lactate to the medium, demonstrating that neurodegeneration is due to diminished lactate export from oligodendrocytes and not import into neurons [7 ]....
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...As detailed below, oligodendrocytes provide metabolic support to axons, but it is the glial glycolysis products (lactate or pyruvate) that are required for axon function and not glucose itself [6 ,7 ]....
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