The Role of Natural Product Chemistry in Drug Discovery
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1,897 citations
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...[2] Butler MS....
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...016 Medicines derived from plants have played a pivotal role in the health care of many cultures, both ancient and modern [1–5]....
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1,760 citations
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...In contrast, pharmaceutical leads originating from synthetic libraries are usually comparably easy to generate and modify using simple chemical approaches (Butler, 2004; Henrich and Beutler, 2013; Li and Vederas, 2009)....
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1,683 citations
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...As such, many pharmaceutical companies have eliminated or scaled down their natural product research (Butler, 2004; Koehn and Carter, 2005)....
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...Drug discovery from medicinal plants led to the isolation of early drugs such as cocaine, codeine, digitoxin, and quinine, in addition to morphine, of which some are still in use (Newman et al., 2000; Butler, 2004; Samuelsson, 2004)....
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...Pharmacognosists, phytochemists, and other natural product scientists will need to continuously improve the quality and quantity of compounds that enter the drug development phase to keep pace with other drug discovery efforts (Butler, 2004)....
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...Despite the recent interest in molecular modeling, combinatorial chemistry, and other synthetic chemistry techniques by pharmaceutical companies and funding organizations, natural products, and particularly medicinal plants, remain an important source of new drugs, new drug leads, and new chemical entities (NCEs) (Newman et al., 2000, 2003; Butler, 2004)....
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...…chemistry, and other synthetic chemistry techniques by pharmaceutical companies and funding organizations, natural products, and particularly medicinal plants, remain an important source of new drugs, new drug leads, and new chemical entities (NCEs) (Newman et al., 2000, 2003; Butler, 2004)....
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1,282 citations
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...Doxorubicin (17) is used to treat acute leukaemia, soft tissue and bone sarcomas, lung cancer, thyroid cancer and both Hodgkins and non-Hodgkins lymphomas (Figure 5) [5,26]....
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...Traditional medicinal practices have formed the basis of most of the early medicines followed by subsequent clinical, pharmacological and chemical studies [5]....
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...Erythromycin (12) has broad spectrum activities against gram-positive cocci and bacilli and is used for mild to moderate, upper and lower respiratory tract infections [5,26]....
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...The class of synthetic derivatives known as the bryologs, such as 53, are derived from bryostatin 1 (54), an antineoplastic compound isolated from the bryozoan, Bulgula neritina [5,113]....
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...It is used for the treatment of severe infection and against susceptible organisms in patients hypersensitive to penicillin (7) [5]....
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