The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.
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Cites background from "The Role of Oxidative Stress and Hy..."
...Mitochondrial dynamics is related to ROS production under hyperglycemic conditions [63,65]....
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Cites background from "The Role of Oxidative Stress and Hy..."
...Since beta cells have a low capacity of the antioxidant defense system, oxidative stress in beta cells is prevalent in DM and plays an important role for the loss of their function in both T1DM and T2DM [45, 48, 55]....
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...Ganjifrockwala et al. in 2017 reported that an antioxidant-rich diet decreased oxidative markers accompanied with improved insulin sensitivity in T2DM patients [143]....
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...Balbaa and colleagues in 2017 induced T2DM-induced oxidative stress and then determined IST elements in the brain of diabetic rats [97]....
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...T2DM is the most prevalent type of DM which accounts for about 90- Hindawi Oxidative Medicine and Cellular Longevity Volume 2020, Article ID 8609213, 13 pages https://doi.org/10.1155/2020/8609213 95% of patients with diabetes and is mainly linked to inadequate response to insulin (reduced insulin sensitivity) and insulin resistance in peripheral tissues [16]....
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...There are different types of DM, but the common subtypes are type 1 DM (T1DM) and type 2 diabetes (T2DM) [16]....
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201 citations
References
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"The Role of Oxidative Stress and Hy..." refers background in this paper
...In addition the formation of peroxynitrite (ONO2 ̄) results from the reaction of superoxide with the free radical nitric oxide (NO) (135)....
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"The Role of Oxidative Stress and Hy..." refers background in this paper
...This leads to their recognition and ubiquitination by the VonHippel-Lindau (VHL) E3 ubiquitin ligase (117)....
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"The Role of Oxidative Stress and Hy..." refers background in this paper
...A major source of ROS within the pancreatic beta cell is the mitochondrial respiratory chain, as observed in other tissues (127,200)....
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