The role of the fallopian tube in the origin of ovarian cancer
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TLDR
In this article, epithelial ovarian cancer classification and genetics, theories regarding cells of origin with a focus on tubal intraepithelial carcinoma, and implications for prevention and screening are reviewed.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2013-11-01 and is currently open access. It has received 250 citations till now. The article focuses on the topics: Ovarian cancer & Fallopian tube.read more
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New insights in the pathophysiology of ovarian cancer and implications for screening and prevention.
TL;DR: New evidence explains difficulties in ovarian cancer screening and helps in forming new recommendations for ovarian cancer risk evaluation and prophylactic treatments.
Journal ArticleDOI
Tubal origin of ‘ovarian’ low-grade serous carcinoma
Jie Li,Nisreen Abushahin,Shujie Pang,Li Xiang,Li Xiang,Setsuko K. Chambers,Oluwole Fadare,Beihua Kong,Wenxin Zheng +8 more
TL;DR: In this paper, the origins of low-grade serous carcinomas (tubal versus ovarian) were investigated by comparatively evaluating the morphologic (secretory and ciliated cell distribution) and immunophenotypic (using antibodies to PAX8, tubulin, calretinin, and Ki67) attributes of its putative precursor lesions, the normal tubal epithelium and the overt malignancy.
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A brief review of the management of platinum-resistant-platinum-refractory ovarian cancer.
Bryan Oronsky,Carolyn M. Ray,Alexander I. Spira,Jane B. Trepel,Corey A. Carter,Hope M. Cottrill +5 more
TL;DR: In recurrent platinum-resistant/platinum-refractory EOC, sequential single-agent salvage chemotherapy is superior to multiagent chemotherapy, and no preferred sequence of single agents is recommended.
Journal ArticleDOI
Estrogen Biosynthesis and Action in Ovarian Cancer
TL;DR: The review gives an overview on ovarian cancer subtypes and explains the role of estrogen in ovarian cancer, where enzymes active to synthesize and metabolize estrogens are described and strategies to target these pathways are discussed.
Journal ArticleDOI
MICU1 drives glycolysis and chemoresistance in ovarian cancer
Prabir K. Chakraborty,Soumyajit Banerjee Mustafi,Xunhao Xiong,Shailendra Kumar Dhar Dwivedi,Vasyl Nesin,Sounik Saha,Min Zhang,Danny N. Dhanasekaran,Muralidharan Jayaraman,Robert S. Mannel,Kathleen N. Moore,Scott McMeekin,Da Yang,Rosemary E. Zuna,Kai Ding,Leonidas Tsiokas,Resham Bhattacharya,Priyabrata Mukherjee +17 more
TL;DR: It is demonstrated that the gatekeeper of mitochondrial Ca2+ uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer, and a significant correlation between pPDH (inactive form of PDH) expression with poor prognosis is observed.
References
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Cancer statistics, 2013
TL;DR: Overall cancer death rates have declined 20% from their peak in 1991 to 2009 and can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket and other underserved populations.
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Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths.
TL;DR: Overall cancer death rates decreased in all racial/ethnic groups in both men and women from 1998 through 2007, with the exception of American Indian/Alaska Native women, in whom rates were stable.
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Ovarian Tumorigenesis : A Proposed Model Based on Morphological and Molecular Genetic Analysis
Ie Ming Shih,Robert J. Kurman +1 more
TL;DR: This model of carcinogenesis reconciles the relationship of borderline tumors to invasive carcinoma and provides a morphological and molecular framework for studies aimed at elucidating the pathogenesis of ovarian cancer.
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Incessant ovulation—a factor in ovarian neoplasia ?
TL;DR: The hypothesis that the extravagant and mostly purposeless ovulations in the human female may have a contributing role in neoplasia of the surface epithelium of the ovary requires additional consideration.
Journal ArticleDOI
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.
Saundra S. Buys,Edward E. Partridge,Amanda Black,Christine Cole Johnson,Lois Lamerato,Claudine Isaacs,Douglas J. Reding,Robert T. Greenlee,Lance A. Yokochi,Bruce Kessel,E. David Crawford,Timothy R. Church,Gerald L. Andriole,Joel L. Weissfeld,Mona N. Fouad,David Chia,Barbara O'Brien,Lawrence R. Ragard,Jonathan D. Clapp,Joshua M. Rathmell,Thomas L. Riley,Patricia Hartge,Paul F. Pinsky,Claire S. Zhu,Grant Izmirlian,Barnett S. Kramer,Anthony B. Miller,Jian Lun Xu,Philip C. Prorok,John K. Gohagan,Christine D. Berg +30 more
TL;DR: Among women in the general US population, simultaneous screening with CA-125 and transvaginal ultrasound compared with usual care did not reduce ovarian cancer mortality.
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