The Role of the Rad55–Rad57 Complex in DNA Repair
Upasana Roy,Eric C. Greene +1 more
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TLDR
In this paper, the Rad51 paralogs play a crucial role in regulating proper levels of homologous recombination, and mutations in the human counterparts have been associated with diseases such as cancer and Fanconi Anemia.Abstract:
Homologous recombination (HR) is a mechanism conserved from bacteria to humans essential for the accurate repair of DNA double-stranded breaks, and maintenance of genome integrity. In eukaryotes, the key DNA transactions in HR are catalyzed by the Rad51 recombinase, assisted by a host of regulatory factors including mediators such as Rad52 and Rad51 paralogs. Rad51 paralogs play a crucial role in regulating proper levels of HR, and mutations in the human counterparts have been associated with diseases such as cancer and Fanconi Anemia. In this review, we focus on the Saccharomyces cerevisiae Rad51 paralog complex Rad55–Rad57, which has served as a model for understanding the conserved role of Rad51 paralogs in higher eukaryotes. Here, we discuss the results from early genetic studies, biochemical assays, and new single-molecule observations that have together contributed to our current understanding of the molecular role of Rad55–Rad57 in HR.read more
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Journal ArticleDOI
Reparative properties of human glioblastoma cells after single exposure to a wide range of X-ray doses
Galina Pavlova,A Belyashova,Ekaterina Savchenko,D. Yu. Panteleev,D Shamadykova,A A Nikolaeva,Svetlana Pavlova,A. V. Revishchin,Denis A. Golbin,Alexander Potapov,Natalia Antipina,Andrey Golanov +11 more
TL;DR: It is demonstrated that the GO1 culture derived from glioblastoma cells from Patient G, who had previously been irradiated, proved to be less sensitive to radiation than the Sus\fP2 gliOBlastoma culture was from Patient S, which had not been exposed to radiation before.
References
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