The role of the thymus in COVID-19 disease severity: implications for antibody treatment and immunization.
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"The role of the thymus in COVID-19 ..." refers background in this paper
...Males and females are affected equally regardless of their race and ethnicity.(17,18) However, the penetrance and disease severity varies among those affected, which is explained by novel genetic and epigenetic differences as well as differ-...
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2,083 citations
2,016 citations
"The role of the thymus in COVID-19 ..." refers background in this paper
...Although COVID-19 mostly affects those with comorbid conditions, even among those without comorbidities, age is a significant risk factor, and there is a direct relationship between age and COVID-19 severity and mortality.(6) This may be explained by the inappropriate COVID-19-induced immune responses in the elderly who are already experiencing...
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...ovascular disease, hypertension, chronic obstructive lung disease and arthritis), and people who develop these comorbidities are known to be at higher risk for severe COVID-19 infection and death.(5,6)...
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1,849 citations
"The role of the thymus in COVID-19 ..." refers background or methods in this paper
...joint TCR excision circle (sjTREC), in naïve T cells by performing real-time polymerase chain reactions (PCR).(68,69) Higher TREC number is associated with better thymic function and repertoire diversity of the memory T-cell population....
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...Higher TREC number is associated with better thymic function and repertoire diversity of the memory T-cell population.(69) Thymic output may also be monitored by conducting flow cytometry in the blood and measuring naïve CD45RA and CD62 ligand positive cells....
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1,491 citations
"The role of the thymus in COVID-19 ..." refers background in this paper
...These molecules bind to diverse mRNA transcripts that play a role in cell function and target mRNA transcripts for degradation.(20,21) MiRNAs play an important role in thymic organogenesis, maturation and involution,(22) and conversely, aging influences miRNA levels....
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