The role of tumour-stromal interactions in modifying drug response: challenges and opportunities.
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Cites background from "The role of tumour-stromal interact..."
...The development of resistance is multifactorial that includes switching of cancer cells to secondary salvage pathways when the primary hallmark is shut [133], epigenetic suppression of tumor suppressor protein activation by miRNAs [134], presence of a subpopulation of highly resistant cancer stem-like cells with enhanced plasticity, such as epithelial-to-mesenchymal transition (EMT) phenotype [135], low drug penetrance (due to desmoplastic reaction or DR in the tumor microenvironment) and others [136]....
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911 citations
Cites background from "The role of tumour-stromal interact..."
...…altered local drug availability, by affecting expression of drug targets, or by changing intrinsic cellular defense mechanisms such as increased repair upon DNA damage or evasion of apoptosis (Sebens and Schafer, 2012; Junttila and de Sauvage, 2013; McMillin et al., 2013; Holle et al., 2016)....
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646 citations
Cites background from "The role of tumour-stromal interact..."
...The mechanism for this unexpected sensitization may include the alteration of signaling pathways in neoplastic cells that are induced by CAFs (McMillin et al., 2013)....
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References
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