The skin: an indispensable barrier
Citations
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2,279 citations
Cites background from "The skin: an indispensable barrier"
...Structurally, the epidermis is a formidable physical barrier, resisting penetration by microorganisms and potential toxins while retaining moisture and nutrients inside the bod...
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1,240 citations
Cites background from "The skin: an indispensable barrier"
...Nascent epidermal keratinocytes formed as a result of cell division by keratinocyte stem cells in the stratum basale undergo a programmed differentiation as they migrate outward toward the surface of the skin to eventually form corneocytes, which are tightly-linked dead but intact cells that form the principle barrier of the outermost epidermal layer [8,9]....
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1,135 citations
Cites background from "The skin: an indispensable barrier"
...They provide the barrier that excludes many toxic agents and prevents dehydratio...
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710 citations
Cites background from "The skin: an indispensable barrier"
...Besides the importance of SC for skin barrier function, other factors contributing to the same purpose are tight junctions (the junctions between keratinocytes in the stratum granulosum), skin-related immune factors, and hair follicle (sebaceous) gland secretions.(20,21) Permeability Penetration through the SC may occur via different pathways: (1) the transappendagael route that includes the transport along sweat pores, hair follicles, and skin (sebaceous) glands; (2) the transcellular SC route; and (3) the paracellular SC route (see Figure 1)....
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694 citations
Cites background from "The skin: an indispensable barrier"
...Several groups of proteins that connect the KC cells of the SG and SS together, including tight junction, gap junction, and adheren junction proteins, are important in maintaining the integrity of this ‘‘second’’ barrier (reviewed in Proksch et al., 2008)....
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References
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