The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin
TL;DR: The results support the idea that membrane ATPases are one target of the neurotoxic effect of pyrethroid compounds.
About: This article is published in Chemosphere.The article was published on 2003-05-01. It has received 107 citations till now. The article focuses on the topics: ATPase & Cypermethrin.
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TL;DR: The review provides an overview of recent studies that suggest additional effects of pyrethroids: developmental neurotoxicity, the production of neuronal death, and action mediated via pyrethroid metabolites, which carry important implications for human health.
285 citations
TL;DR: It is revealed that SSRIs are readily available in fish, biologically active and corroborates previous findings on the serotonergic properties of municipal effluents to aquatic organisms.
138 citations
Cites background or methods from "The synaptosomal membrane bound ATP..."
...ATP ? ADP + inorganic phosphate) that can be easily measured (Kakko et al., 2003)....
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...Total serotonin content and the activity of Na/K-dependent and Mg-dependent ATPases in synaptosomal membranes were determined in the brain of brook trout based on a previous methodology (Kakko et al., 2003)....
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...Na/K-ATPase activity determinations Total serotonin content and the activity of Na/K-dependent and Mg-dependent ATPases in synaptosomal membranes were determined in the brain of brook trout based on a previous methodology (Kakko et al., 2003)....
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...ADP + inorganic phosphate) that can be easily measured (Kakko et al., 2003)....
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TL;DR: It is inferred that beta-CYP damaged the structure of testes and decreased sperm output by inducing oxidative stress.
112 citations
Cites background from "The synaptosomal membrane bound ATP..."
...Cypermethrin exerts its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane [8,9]....
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TL;DR: The data demonstrate that cypermethrin induces systemic genotoxicity in mammals as it causes DNA damage in vital organs like brain, liver, kidney, apart from that in the hematopoietic system.
Abstract: Cypermethrin is the most widely used Type II pyrethroid pesticide because of its high effectiveness against target species and its low mammalian toxicity reported so far. It is a fast-acting neurotoxin and is known to cause free radical-mediated tissue damage. The present study investigates the genotoxic effects of cypermethrin in multiple organs (brain, kidney, liver, spleen) and tissues (bone marrow, lymphocytes) of the mouse, using the alkaline comet assay. Male Swiss albino mice were given 12.5, 25, 50, 100, 200 mg/kg BW of cypermethrin intraperitoneally, daily for 5 consecutive days. A statistically significant ( p kidney > bone marrow > liver > lymphocytes, as evident by the OTM. Our data demonstrate that cypermethrin induces systemic genotoxicity in mammals as it causes DNA damage in vital organs like brain, liver, kidney, apart from that in the hematopoietic system.
111 citations
TL;DR: Results indicate that estrogenic chemicals are likely at play, and the increased dopamine and decreased serotonin ATP-dependent transport suggest that the municipal plume was serotonergic for mussels located at the downstream sites.
Abstract: Freshwater mussels, Elliptio complanata, were caged in special benthic pens and were immersed at one upstream (Ups) site and two downstream sites (8 and 11 km) of a primary-treated municipal effluent plume for 1 year. The levels of metallothionein-like proteins (MT), lipid peroxidation, protein-free DNA strands and glutathione S-transferase (GST) activity were assayed in digestive gland, gill and gonad tissues to evaluate biological effects and damage. The levels of monoamines (serotonin and dopamine) in nerve ganglia, ATP-dependent transport activity and monoamine oxidase (MAO) activity were also investigated in the homogenates, synaptosomes and mitochondria, respectively. Results showed that significant amounts of sediment accumulated in cages and 82% of mussels survived the yearlong exposure period at the downstream sites. MT-like proteins were induced in all tissues with the following response intensity: gill (3-fold), digestive gland (1.4-fold) and gonad tissues (1.3-fold). Lipid peroxidation decreased (2.5-fold) in digestive gland but increased in gill (1.6-fold) and in gonad tissues (1.5-fold). GST activity was readily increased in digestive gland (2.5-fold), suggesting the presence of organic contaminants in the plume. Levels of protein-free DNA strands did not vary significantly in digestive gland and gill tissues but were significantly reduced in gonad tissues (2.5-fold) relative to the upstream site. In visceral nerve ganglia, both serotonin and ATP-dependent serotonin transport decreased 1.7-fold with a 4-fold increase of 5-hydroxyindole acetate (5-HIAA, a serotonin metabolite) level relative to the upstream site. However, MAO activity was somewhat reduced at downstream sites (0.7- to 0.9-fold of the activity at the upstream site). Dopamine levels were found to be decreased (1.5-fold), but dopamine ATP-dependent transport activity was increased 1.8-fold, suggesting reduced dopaminergic activity. These results indicate that estrogenic chemicals are likely at play, and the increased dopamine and decreased serotonin ATP-dependent transport suggest that the municipal plume was serotonergic for mussels located at the downstream sites. Mussels exposed for 1 year display a complex but characteristic pattern of responses that could lead to harmful health effects including neuroendocrine disruption of reproduction.
101 citations
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01 Jan 1986
TL;DR: Casarett and Doull's Toxicology: The Basic Science of Poisons as mentioned in this paper is the most complete and up-to-date overview of the biomedical and environmental aspects of toxicology.
Abstract: The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology - Now more complete, up-to-date, and in full color. It is a Doody's Core Title for 2015! New to the Eighth Edition Full-Color design to allow for a clearer interpretation of the basic components of toxicology featured throughout the text. Expanded tables, illustrations, and other visuals are updated with state-of-the-art standards that makes this edition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format. New Chapters include "Toxic Effects of Calories" and "Toxic Effects of Nanoparticles." The world's leading and most authoritative textbook on poisons has more to offer students, toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's Toxicology: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references.
3,074 citations
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01 Jan 1982
TL;DR: Principles of Toxicology Harming and Helping Through Time: The History of toxicology, R.R. Lane and J.F. Borzelleca and Principles and Methods for Renal Toxicology, Y.D. Doolittle Short-Term, Subchronic, and Chronic Toxicology Studies, N.H. Wilson, J.J. Kapp, Jr.
Abstract: Principles of Toxicology Harming and Helping Through Time: The History of Toxicology, R.W. Lane and J.F. Borzelleca The Use of Toxicology in the Regulatory Process, B.D. Beck, E.J. Calabrese, T.M. Slayton, and R. Rudel Metabolism: A Determinant of Toxicity, R. Kemper, J.R. Hayes, and M.S. Bogdanffy Toxicokinetics, A.G. Renwick Physiologically Based Pharmacokinetic and Toxicokinetic Models, K.Krishnan and M.E. Andersen Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology, D. Robertson, S. Beushausen, and W. Pennie The Toxicologic Assessment of Pharmaceutical and Biotechnology Products, M.A. Dorato, C. McMillian, and M.J. Vodicnik Statistics for Toxicologists, S. C. Gad Quantitative Extrapolations in Toxicology, J.V. Rodricks, D.M. Gaylor, and D. Turnbull The Practice of Exposure Assessment, D.J. Paustenbach and A.K. Madl Epidemiology for Toxicologists, R.R. Cook Principles of Pathology for Toxicology Studies, S.R. Frame and P.C. Mann The Information Infrastructure of Toxicology, P. Wexler, P. Hakkinen, P. Nance, A. Parker, and J. Patterson Agents Foodborne Toxicants, C.S. Reddy and A. Wallace Hayes Solvents and Industrial Hygiene, D.L. Dahlstrom and M. Buckalew Crop Protection Chemicals: Mechanism of Action and Hazard Profiles, C.B. Breckenridge and J.T. Stevens Metals, J.C. Merrill, J.J.P. Morton, and S.D. Soileau Ionizing Radiation, L.G. Cockerham, T.L. Walden, Jr., C.E. Dallas, G.A. Mickley, Jr., and M.A. Landauer Plant and Animal Toxins, F.W. Oehme and D.E. Keyler Methods The Use of Laboratory Animals in Toxicology Research, W.J. White, C.T. Hawk, and M.A. Vasbinder Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods, W.S. Stokes and L.M. Schechtman Acute Toxicity and Eye Irritancy, M.E. Blazka and A. Wallace Hayes Genetic Toxicology, D.J. Brusick, W.R. Fields, B.C. Myhr, and D.J. Doolittle Short-Term, Subchronic, and Chronic Toxicology Studies, N.H. Wilson, J.F. Hardisty, and J.R. Hayes Principles of Testing for Carcinogenic Activity, G.M. Williams, M.J. Iatropoulos, and H.G. Enzmann Principles of Clinical Pathology for Toxicology Studies, R.L. Hall and N.E. Everds Dermatotoxicology, B.B. Hayes, E. Patrick, and H. Maibach Inhalation Toxicology, R. Valentine and G.L. Kennedy Detection and Evaluation of Chemically Induced Liver Injury, G.L. Plaa and M.Charbonneau Principles and Methods for Renal Toxicology, L.H. Lash Gastrointestinal Toxicology, R.W. Kapp, Jr. Principles and Methods of Cardiac Toxicology, Y.J. Kang Assessment of Male Reproductive Toxicity, S.D. Perreault, G.R. Klinefelter, and E. Clegg Test Methods for Assessing Female Reproductive and Developmental Toxicology, M.S. Christian Hormone Assays and Endocrine Function, R.W. Kapp, Jr., and J.A. Thomas Immunotoxicology: Effects of and Response to Drugs and Chemicals, J.H. Dean, R.V. House, and M.I. Luster Assessment of Behavioral Toxicity, D.A. Cory-Slechta and B. Weiss Application of Isolated Organ Perfusion Techniques in Toxicology, H.M. Mehendale Organelles as Tools in Toxicology, B.A. Fowler, M.L. Haasch, K.S. Squibb, and A. Wallace Hayes Analysis and Characterization of Enzymes and Nucleic Acids, F.P. Guengerich and C.J. Bartleson Modern Instrumental Methods for Studying Mechanisms of Toxicology, P.A. Crooks, D.R. Worthen, G.D. Byrd, J.D. deBethizy, and W.S. Caldwell Methods in Environmental Toxicology, M.A. Lewis, A. Fairbrother, and R.E. Menzer Glossary Index
1,637 citations
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13 Apr 1996TL;DR: In this paper, the authors present a model for estimating the toxicity of a mixture of organisms in the field using a K-value analysis, which depends on the properties of individual organisms and their density.
Abstract: POLLUTANTS AND THEIR FATE IN ECOSYSTEMS Major Classes of Pollutant Inorganic Ions Organic Pollutants Organometallic Compounds Radioactive isotopes Gaseous Pollutants Summary Further Reading Routes by Which Pollutants Enter Ecosystems Entry into Surface Waters Contamination of Land Discharge into the Atmosphere Quantification of Release of Pollutants Summary Further Reading Long-Range Movements and Global Transport of Pollutants Factors Determining Movement and Distribution of Pollutants Transport in Water Transport in Air Models for Environmental Distribution of Chemicals Summary Further Reading The Fate of Metals and Radioactive Isotopes in Contaminated Ecosystems Introduction Terrestrial Ecosystems Aquatic Systems Summary Further Reading The Fate of Organic Pollutants in Individuals and in Ecosystems Fate within Individual Organisms Organic Pollutants in Terrestrial Ecosystems Organic Pollutants in Aquatic Ecosystems Summary Further Reading EFFECTS OF POLLUTANTS ON INDIVIDUAL ORGANISMS Toxicity Testing General Principles Determination of the Toxicity of Mixtures Toxicity testing with Terrestrial Organisms Toxicity testing with Aquatic Organisms Risk Assessment Toxicity Testing in the Field Alternative Methods in Ecotoxicological Testing Summary Further Reading Biochemical Effects of Pollutants Introduction Protective Biochemical Responses Molecular Mechanisms of Toxicity Examples of Molecular Mechanisms of Toxicity Summary Further Reading Physiological Effects of Pollutants Introduction Effects of Pollutants at the Cellular Level Effects at the Organ Level Effects at the Whole Organism Level in Animals Effects on Plants Energy Costs of Physiological Change Summary Further Reading Interactive Effects of Pollutants Introduction Additive Effects Potentiation of Toxicity Potentiation Due to Inhibition of Detoxification Potentiation Due to Increased Activation The Detection of Potentiation in the Field Summary Further Reading Biomarkers Classification of Biomarkers Specificity of Biomarkers Relationship of Biomarkers to Adverse Effects Discussion of Specific Biomarkers Role of Biomarkers in Environmental Risk Assessment Summary Further Reading In situ Biological Monitoring Introduction Community Effects (Type 1 Biomonitoring) Bioconcentration of Pollutants (Type 2 Biomonitoring) Effects of Pollutants (Type 3 Biomonitoring) Genetically Based Resistance to Pollution (Type 4 Biomonitoring) Conclusions Summary Further Reading EFFECTS OF POLLUTANTS ON POPULATIONS AND COMMUNITIES Changes in Numbers: Population Dynamics Population Abundance Population Growth Rate Population Growth Rate Depends on the Properties of Individual Organisms Density Dependence Identifying Which Factors are Densitivity Dependent: K-Value Analysis Interactions Between Species Field Studies: Three Case Studies Modelling the Effects of Skylarks for Risk Assessment Purposes Summary Further Reading Evolution of Resistance to Pollution Chronic Pollution is Environmental Change The Evolutionary Process in a Constant Environment The Evolution of Resistance When There is a Mortality-Production Trade-Off Evolutionary Responses to Environmental Change Resistance is Often Monogenic Case Studies Summary Further Reading Changes in Communities and Ecosystems Introduction Soil Processes: The Functional Approach Changes in Composition of Communities: The Structural Approach Global Processes Summary Further Reading Extrapolating From Molecular Interactions to Consequent Effects at the Population Level Introduction The Translation of Toxic Effects Across Organizational Boundaries Biomarker Strategies Biomarkers and Environmental Risk Assessment Summary Further Readings Biomarkers in Population Studies DDE-Induced Eggshell Thinning in Raptorial and Fish-Eating Birds Reproductive Failure of Fish-Eating Birds on the Great Lakes of North America Reproductive Failure of Molluscs Caused by Tributyl Tin Forest Spraying in Eastern Canada to Control Spruce Budworm Summary Further Reading Appendix: Introduction to population projection matrices Glossary Bibliography Index
860 citations