Journal ArticleDOI
The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer.
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TLDR
The GPS/mGPS is the most extensively validated of the systemic inflammation-based prognostic scores and therefore may be used in the routine clinical assessment of patients with cancer and provides a well defined therapeutic target for future clinical trials.About:
This article is published in Cancer Treatment Reviews.The article was published on 2013-08-01. It has received 1039 citations till now.read more
Citations
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Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis
Arnoud J. Templeton,Mairéad G McNamara,Bostjan Seruga,Francisco E. Vera-Badillo,Priya Aneja,Alberto Ocaña,Raya Leibowitz-Amit,Guru Sonpavde,Jennifer J. Knox,Ben Tran,Ian F. Tannock,Eitan Amir +11 more
TL;DR: A high NLR is associated with an adverse OS in many solid tumors, and its addition to established prognostic scores for clinical decision making warrants further investigation.
Journal ArticleDOI
ESPEN guidelines on nutrition in cancer patients
Jann Arends,Patrick Bachmann,Vickie E. Baracos,Nicole Barthelemy,Hartmut Bertz,Federico Bozzetti,Kenneth C. H. Fearon,Elisabeth Hütterer,Elizabeth Isenring,Stein Kaasa,Zeljko Krznaric,Barry Laird,Maria Larsson,Alessandro Laviano,Stefan Mühlebach,Maurizio Muscaritoli,Line Merethe Oldervoll,Paula Ravasco,Tora Skeidsvoll Solheim,Florian Strasser,Marian A. E. de van der Schueren,Jean-Charles Preiser +21 more
TL;DR: These evidence-based guidelines were developed to translate current best evidence and expert opinion into recommendations for multi-disciplinary teams responsible for identification, prevention, and treatment of reversible elements of malnutrition in adult cancer patients.
Journal ArticleDOI
Cancer-related inflammation and treatment effectiveness
TL;DR: The complex interplay between local immune responses and systemic inflammation, and their influence on clinical outcomes, are examined, and potential anti-inflammatory interventions for patients with cancer are proposed.
Journal ArticleDOI
The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer
Graeme J.K. Guthrie,Kellie A. Charles,Campbell S.D. Roxburgh,Paul G. Horgan,Donald C. McMillan,Stephen Clarke +5 more
TL;DR: The present systematic review examines and comments on the clinical utility of the neutrophil-lymphocyte ratio, which has shown that NLR is elevated in patients with more advanced or aggressive disease evidenced by increased tumour stage, nodal stage, number of metastatic lesions and as such these patients may represent a particularly high-risk patient population.
Journal ArticleDOI
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
TL;DR: How a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment is discussed.
References
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Journal ArticleDOI
Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer
Jennifer S. Temel,Joseph A. Greer,Alona Muzikansky,Emily R. Gallagher,Sonal Admane,Vicki A. Jackson,Constance Dahlin,Craig D. Blinderman,Juliet Jacobsen,William F. Pirl,J. Andrew Billings,Thomas J. Lynch +11 more
TL;DR: Among patients with metastatic non-small-cell lung cancer, early palliative care led to significant improvements in both quality of life and mood and, as compared with patients receiving standard care, patients received less aggressive care at the end of life but longer survival.
Journal ArticleDOI
Role of systemic inflammatory response in predicting survival in patients with primary operable cancer
TL;DR: Good evidence is demonstrated that there is now good evidence that preoperative measures of the systemic inflammatory response predict cancer survival, independent of tumor stage, in primary operable cancer.
Journal ArticleDOI
Systemic inflammation, nutritional status and survival in patients with cancer.
TL;DR: Systemic inflammation-based prognostic scores not only identify patients at risk but also provide well defined therapeutic targets for future clinical trials targeting nutritional decline.
Journal ArticleDOI
A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
M J Proctor,David S. Morrison,Dinesh Talwar,Steven M. Balmer,Colin D. Fletcher,Denis St. J. O’Reilly,Alan K. Foulis,Paul G. Horgan,Donald C. McMillan +8 more
TL;DR: The results of the present study show that systemic inflammation-based scores, in particular the mGPS and PI, have prognostic value in cancer independent of tumour site.
Journal ArticleDOI
Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer.
TL;DR: A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) was comparable in prognostic value to that based on stage and performance status in patients with inoperable non-small-cell lung cancer.