The value of plants used in traditional medicine for drug discovery.
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TLDR
This review describes and discusses several approaches to selecting higher plants as candidates for drug development with the greatest possibility of success and identifies and discusses advantages and disadvantages of using plants as starting points for drugDevelopment, specifically those used in traditional medicine.Abstract:
In this review we describe and discuss several approaches to selecting higher plants as candidates for drug development with the greatest possibility of success. We emphasize the role of information derived from various systems of traditional medicine (ethnomedicine) and its utility for drug discovery purposes. We have identified 122 compounds of defined structure, obtained from only 94 species of plants, that are used globally as drugs and demonstrate that 80% of these have had an ethnomedical use identical or related to the current use of the active elements of the plant. We identify and discuss advantages and disadvantages of using plants as starting points for drug development, specifically those used in traditional medicine.read more
Citations
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Journal ArticleDOI
Natural products: a continuing source of novel drug leads.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: This review traces natural products drug discovery, outlining important drugs from natural sources that revolutionized treatment of serious diseases and effective drug development depends on multidisciplinary collaborations.
Journal ArticleDOI
Discovery and resupply of pharmacologically active plant-derived natural products: A review.
Atanas G. Atanasov,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Thomas Linder,Christoph Wawrosch,Pavel Uhrin,Veronika Temml,Limei Wang,Stefan Schwaiger,Elke H. Heiss,Judith M. Rollinger,Judith M. Rollinger,Daniela Schuster,Johannes M. Breuss,Valery N. Bochkov,Marko D. Mihovilovic,Brigitte Kopp,Rudolf Bauer,Verena M. Dirsch,Hermann Stuppner +19 more
TL;DR: While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future.
Journal ArticleDOI
Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.
TL;DR: This review provides a number of recommendations that will help to define a more sound 'proof-of-concept' for antibacterial, antifungal, antiviral and antiparasitic potential in natural products.
Journal ArticleDOI
A historical overview of natural products in drug discovery.
TL;DR: A review of historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery, and a discussion of how natural product chemistry has resulted in the identification of many drug candidates are highlighted.
Journal ArticleDOI
Biological activities and distribution of plant saponins.
TL;DR: Isolation studies of saponins were examined to determine which are the more commonly studied plant families and in which families saponin have been identified.
References
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Book
The evolution and classification of flowering plants
TL;DR: The evolution and classification of flowering plants is studied in detail in the book “Flowering plants: Evolution and Classification of Flowers, 2nd Ed.” (2003).
Journal ArticleDOI
Natural Products in Drug Discovery and Development
Journal ArticleDOI
The influence of natural products upon drug discovery.
Journal ArticleDOI
Medicinal plants in therapy.
TL;DR: This update article presents a list of plant-derived drugs, with the names of the plant sources, and their actions or uses in therapy.
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