The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies.
Frances Rees,Frances Rees,Michael Doherty,Matthew J. Grainge,Peter Lanyon,Peter Lanyon,Weiya Zhang +6 more
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TLDR
There are worldwide differences in the incidence and prevalence of SLE that vary with sex, age, ethnicity and time and further study of genetic and environmental risk factors may explain the reasons for these differences.Abstract:
Objectives The aim was to review the worldwide incidence and prevalence of SLE and variation with age, sex, ethnicity and time. Methods A systematic search of MEDLINE and EMBASE search engines was carried out using Medical Subject Headings and keyword search terms for Systemic Lupus Erythematosus combined with incidence, prevalence and epidemiology in August 2013 and updated in September 2016. Author, journal, year of publication, country, region, case-finding method, study period, number of incident or prevalent cases, incidence (per 100 000 person-years) or prevalence (per 100 000 persons) and age, sex or ethnic group-specific incidence or prevalence were collected. Results The highest estimates of incidence and prevalence of SLE were in North America [23.2/100 000 person-years (95% CI: 23.4, 24.0) and 241/100 000 people (95% CI: 130, 352), respectively]. The lowest incidences of SLE were reported in Africa and Ukraine (0.3/100 000 person-years), and the lowest prevalence was in Northern Australia (0 cases in a sample of 847 people). Women were more frequently affected than men for every age and ethnic group. Incidence peaked in middle adulthood and occurred later for men. People of Black ethnicity had the highest incidence and prevalence of SLE, whereas those with White ethnicity had the lowest incidence and prevalence. There appeared to be an increasing trend of SLE prevalence with time. Conclusion There are worldwide differences in the incidence and prevalence of SLE that vary with sex, age, ethnicity and time. Further study of genetic and environmental risk factors may explain the reasons for these differences. More epidemiological studies in Africa are warranted.read more
Citations
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Epidemiology of systemic lupus erythematosus: an update.
George Stojan,Michelle Petri +1 more
TL;DR: Sex, race, and ethnicity significantly affect SLE incidence, prevalence, and mortality.
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Global epidemiology of systemic lupus erythematosus
Megan R.W. Barber,Cristina Drenkard,Titilola Falasinnu,Alberta Hoi,Anselm Mak,Nien Yee Kow,Elisabet Svenungsson,Jonna Peterson,Ann E. Clarke,Rosalind Ramsey-Goldman +9 more
TL;DR: In this article, the authors summarize and discuss the existing evidence on the incidence, prevalence and mortality of systemic lupus erythematosus across different world regions, with a focus on studies from the past 5 years.
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Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus.
Yuri Kotliarov,Rachel Sparks,Andrew J. Martins,Matthew P. Mulé,Matthew P. Mulé,Yong Lu,Meghali Goswami,Lela Kardava,Romain Banchereau,Romain Banchereau,Virginia Pascual,Virginia Pascual,Angelique Biancotto,Jinguo Chen,Pamela L. Schwartzberg,Neha Bansal,Candace C. Liu,Foo Cheung,Susan Moir,John S. Tsang +19 more
TL;DR: Simultaneous single-cell protein and transcriptome analysis identifies a baseline immune circuit associated with antibody responses to vaccination in healthy individuals and the severity of disease flares in patients with a subtype of systemic lupus erythematosus.
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Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus.
Taco A van der Meulen,Hermie J. M. Harmsen,Arnau Vich Vila,Alexander Kurilshikov,Silvia C Liefers,Alexandra Zhernakova,Jingyuan Fu,Cisca Wijmenga,Rinse K. Weersma,Karina de Leeuw,Hendrika Bootsma,Fred K L Spijkervet,Arjan Vissink,Frans G. M. Kroese +13 more
TL;DR: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS andSLE patients.
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The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis
TL;DR: This comprehensive meta-analysis provides epidemiological evidence supporting the associations between SLE and cancer risk and could be utilized to drive public policies and to help guide personalized medicine to better manage Sle and reduce associated cancer morbidity and mortality.
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