Infectious stomatitis represents the most common oral cavity ailments. Current therapy is insufficiently effective because of the short residence time of topical liquid or semisolid medical formulations. An innovative application form based on bioadhesive polymers featuring prolonged residence time on the oral mucosa may be a solution to this challenge. This formulation consists of a mucoadhesive oral film with incorporated nanocomposite biomaterial that is able to release the drug directly at the target area. This study describes the unique approach of preparing mucoadhesive oral films from carmellose with incorporating a nanotechnologically modified clay mineral intercalated with chlorhexidine. The multivariate data analysis was employed to evaluate the influence of the formulation and process variables on the properties of the medical preparation. This evaluation was complemented by testing the antimicrobial and antimycotic activity of prepared films with the aim of finding the most suitable composition for clinical application. Generally, the best results were obtained with sample containing 20 mg of chlorhexidine diacetate carried by vermiculite, with carmellose in the form of nonwoven textile in its structure. In addition to its promising physicomechanical, chemical, and mucoadhesive properties, the formulation inhibited the growth of Staphylococcus and Candida; the effect was prolonged for tens of hours.

The x-ray identification and crystal structures of clay minerals

Research Article Carmellose Mucoadhesive Oral Films Containing Vermiculite/Chlorhexidine Nanocomposites as Innovative Biomaterials for Treatment of Oral Infections

Ballarat sepiolite appears to have formed by alteration of previously existing minerals, primarily saponite, rather than by direct crystallization, during cyclic inundation by a Pleistocene lake. The sepiolite appears as a coating on fracture surfaces of metamorphosed limestone in combination with saponite and diopside. Ballarat sepiolite occurs as a naturally pure and well crystallized material, very similar to Two Crows sepiolite from Nevada, so that its diffraction pattern has more peaks resolved than patterns of sepiolite given for specimens from other sources, such as Kuzu, Japan. Also, the infrared absorption spectra are more sharply defined.

Ballarat Sepiolite, Inyq County, California

Tentatives d'intercalation de molecules neutres dipolaires dans les plans de base de la structure lamellaire du materiau supraconducteur

The x-ray identification and crystal structures of clay minerals

Citations

Research Article Carmellose Mucoadhesive Oral Films Containing Vermiculite/Chlorhexidine Nanocomposites as Innovative Biomaterials for Treatment of Oral Infections

Ballarat Sepiolite, Inyq County, California

Superconducting BiSrCaCuO system and organic reaction

On the occurrence and clay minerals of Torai “Roseki” Clay in Korea

Physical Properties of Smectite Bearing Soft Rocks (Part1)

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