The zebrafish as a model for complex tissue regeneration
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TLDR
Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals.About:
This article is published in Trends in Genetics.The article was published on 2013-11-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Genetic model & Zebrafish.read more
Citations
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Journal ArticleDOI
Use of Zebrafish in Drug Discovery Toxicology
Steven Cassar,Isaac Adatto,Jennifer L. Freeman,Joshua T. Gamse,Iñaki Iturria,Christian Lawrence,Arantza Muriana,Randall T. Peterson,Steven Van Cruchten,Leonard I. Zon +9 more
TL;DR: The zebrafish model is a bridge between in vitro assays and mammalian in vivo studies, which is powerful in its breadth of application and tractability for research, and the 3Rs value that it can deliver is discussed.
Journal ArticleDOI
Müller glia: Stem cells for generation and regeneration of retinal neurons in teleost fish.
TL;DR: Understanding the specific properties of fish Müller glia that facilitate their robust capacity to generate retinal neurons will inform and inspire new clinical approaches for treating blindness and visual loss with regenerative medicine.
Journal ArticleDOI
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish
TL;DR: Evidence is found that Neuregulin1 (Nrg1), previously shown to have mitogenic effects on mammalian cardiomyocytes, is sharply induced in perivascular cells after injury to the adult zebrafish heart and is identified as a potent, induced mitogen for the endogenous adult heart regeneration program.
Journal ArticleDOI
Modulation of tissue repair by regeneration enhancer elements
Junsu Kang,Jianxin Hu,Ravi Karra,Amy L. Dickson,Valerie A. Tornini,Gregory Nachtrab,Matthew Gemberling,Joseph A. Goldman,Brian L. Black,Kenneth D. Poss +9 more
TL;DR: Evidence is provided for ‘tissue regeneration enhancer elements’ (TREEs) that trigger gene expression in injury sites and can be engineered to modulate the regenerative potential of vertebrate organs.
Journal ArticleDOI
The art of fin regeneration in zebrafish
TL;DR: This review summarizes the current knowledge about the cellular and molecular mechanisms of blastema formation, and discusses several studies related to the regulation of growth and morphogenesis during fin regeneration.
References
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Journal ArticleDOI
Efficient genome editing in zebrafish using a CRISPR-Cas system
Woong Y. Hwang,Yanfang Fu,Deepak Reyon,Morgan L. Maeder,Shengdar Q. Tsai,Jeffry D. Sander,Randall T. Peterson,Randall T. Peterson,Jing-Ruey J. Yeh,J. Keith Joung +9 more
TL;DR: It is shown that the CRISPR-Cas system functions in vivo to induce targeted genetic modifications in zebrafish embryos with efficiencies similar to those obtained using zinc finger nucleases and transcription activator-like effector nucleases.
Journal ArticleDOI
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller,Siyuan Tan,Guijuan Qiao,Kyle A. Barlow,Jianbin Wang,Danny F Xia,Xiangdong Meng,David Paschon,Elo Leung,Sarah J. Hinkley,Gladys P Dulay,Kevin Hua,Irina Ankoudinova,Gregory J. Cost,Fyodor D. Urnov,H. Steve Zhang,Michael C. Holmes,Lei Zhang,Philip D. Gregory,Edward J. Rebar +19 more
TL;DR: This study identifies TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and uses them to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%.
Journal ArticleDOI
Transient regenerative potential of the neonatal mouse heart
Enzo R. Porrello,Ahmed I. Mahmoud,Emma Simpson,Joseph A. Hill,James A. Richardson,Eric N. Olson,Hesham A. Sadek +6 more
TL;DR: It is found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age, which means that for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.
Journal ArticleDOI
Heart Regeneration in Zebrafish
TL;DR: It is demonstrated histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection, showing that injury-induced cardiomyocyte proliferation in zebra fish can overcome scar formation, allowing cardiac muscle regeneration.
Journal ArticleDOI
Production of clones of homozygous diploid zebra fish ( Brachydanio rerio )
TL;DR: Clones of homozygous fish have been produced from individual homozygotes and associated genetic methods facilitate genetic analyses of this vertebrate.
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