Therapeutic potential of opioid/cannabinoid combinations in humans: Review of the evidence.
Shanna Babalonis,Sharon L. Walsh +1 more
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TLDR
There is a groundswell of public advocacy supporting the use of cannabis and cannabinoids to replace opioid analgesics or to reduce opioid use; however, the extant controlled clinical data do not support the role of cannabinoids for opioid replacement or opioid-sparing effects when treating opioid use disorder or chronic pain.About:
This article is published in European Neuropsychopharmacology.The article was published on 2020-04-06 and is currently open access. It has received 17 citations till now. The article focuses on the topics: Endogenous opioid & Opioid overdose.read more
Citations
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Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies
Suzanne Nielsen,Louisa Picco,Bridin Murnion,Bryony L. Winters,Justin Matheson,Myfanwy Graham,Gabrielle Campbell,Laila Parvaresh,Kok Eng Khor,Brigid Betz-Stablein,Michael Farrell,Nicholas Lintzeris,Bernard Le Foll +12 more
TL;DR: A recent systematic review on the opioid-sparing effects of cannabinoids considered preclinical and clinical studies where the outcome was analgesia or opioid dose requirements as mentioned in this paper , found that the median effective dose (ED 50 ) administered with delta-9-tetrahydrocannabinol was 3.5 times lower (95% CI 2.04, 6.03) than the ED 50 of morphine alone.
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The endocannabinoid system - current implications for drug development.
TL;DR: In this article, the state of the art for compounds affecting the endocannabinoid (eCB) system is described with a focus on the treatment of pain, and clinical experience with ∆9 -tetrahydracannabinol and medical cannabis in chronic non-cancer pain indicates that there are differences between the benefits perceived by patients and the at best modest effect seen in meta-analyses of randomized controlled trials.
Journal ArticleDOI
Cellular and behavioral basis of cannabinioid and opioid interactions: Implications for opioid dependence and withdrawal.
TL;DR: A review of the potential relationship of these neural systems in addiction-related processes is presented in this paper, where the authors focus on how these endogenous signaling systems interact in the brain.
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Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory pain model.
Kelly E. Dunn,Cecilia L. Bergeria,Andrew S. Huhn,Traci J. Speed,Chung Jung Mun,Ryan Vandrey,Claudia M. Campbell +6 more
TL;DR: In this paper, the authors evaluated the effect of delta-9-tetrahydrocannabinol (THC; dronabinol) on hydromorphone-based analgesia, abuse liability, and cognitive performance.
References
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Journal ArticleDOI
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Penny Whiting,Penny Whiting,Robert Wolff,Sohan Deshpande,Marcello Di Nisio,Steven Duffy,Adrian V. Hernandez,Adrian V. Hernandez,J. Christiaan Keurentjes,Shona H. Lang,Kate Misso,Steve Ryder,Simone Schmidlkofer,Marie Westwood,Jos Kleijnen +14 more
TL;DR: There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.
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Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ1 Opioid Receptor Mechanism
TL;DR: Delta9-THC and heroin exert similar effects on mesolimbic dopamine transmission through a common mu1 opioid receptor mechanism located in the ventral mesencephalic tegmentum.
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The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
TL;DR: Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.
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Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010
TL;DR: Examination of the association between medical cannabis laws and opioid analgesic overdose mortality in each year after implementation of the law showed that such laws were associated with a lower rate of overdose mortality that generally strengthened over time.
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Two New Rating Scales for Opiate Withdrawal
Leonard Handelsman,Kenneth J. Cochrane,Marvin J. Aronson,Robert Ness,Karen J. Rubinstein,Philip D. Kanof +5 more
TL;DR: In this paper, two rating scales for measuring the signs and symptoms of opiate withdrawal are presented: Subjective Opiate Withdrawal Scale (SOWS) contains 16 symptoms whose intensity the patient rates on a scale of 0 (not at all) to 4 (extremely).