Journal ArticleDOI
Thermochromic Polyvinyl Alcohol-Iodine Hydrogels with Safe Threshold Temperature for Infectious Wound Healing
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TLDR
In this paper, a blue polyvinyl alcohol-iodine (PAI) complex-based antibacterial hydrogel is explored as a new generation of biocompatible iodine-based bactericides.Abstract:
Iodophor (povidone-iodine) has been widely used for antibacterial applications in the clinic. Yet, limited progress in the field of iodine-based bactericides has been achieved since the invention of iodophor. Herein, a blue polyvinyl alcohol-iodine (PAI) complex-based antibacterial hydrogel is explored as a new generation of biocompatible iodine-based bactericides. The obtained PAI hydrogel maintains laser triggered liquefaction, thermochromic, and photothermal features for highly efficient elimination of bacteria. In vitro antibacterial test reveals that the relative bacteria viabilities of Escherichia coli (E.coli) and methicillin-resistant Staphylococcus aureus (MRSA) incubated with PAI hydrogel are only 8% and 3.8%, respectively. Upon single injection of the PAI hydrogel, MRSA-infected open wounds can be efficiently healed in only 5 days, and the healing speed is further accelerated by laser irradiation due to the dynamic interaction between iodine and polyvinyl alcohol, causing up to ∼29% of wound area being closed on day 1. In addition, a safe threshold temperature of skin scald (∼45 °C) emerges for PAI hydrogels because of thermochromic properties, avoiding thermal injuries during irradiation. In addition, no observed toxicity or skin irritation is observed for the PAI hydrogel. This work expands the category of iodine-based bactericides for safe and controllable management of infected wounds.read more
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A Novel Cascade Nanoreactor Integrating Two-Dimensional Pd-Ru Nanozyme, Uricase and Red Blood Cell Membrane for Highly Efficient Hyperuricemia Treatment.
Jiang Ming,Tianbao Zhu,Jingchao Li,Zichen Ye,Changrong Shi,Zhide Guo,Jingjuan Wang,Xiaolan Chen,Nanfeng Zheng +8 more
TL;DR: In this paper, a two-dimensional Pd-Ru nanozyme is prepared and then integrated with uricase and red blood cell (RBC) membrane to fabricate a tandem nanoreactor, PdRu/Uricase@RBC, for hyperuricemia treatment.
Journal ArticleDOI
Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing
TL;DR: The recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling is summarized.
Journal ArticleDOI
Dual Thermo-Responsive and Strain-Responsive Ionogels for Smart Windows and Temperature/Motion Monitoring.
TL;DR: In this article , a stretchable, dual thermo-responsive and strain-responsive ionogel has been synthesized by one-step photopolymerization, which shows an ultrahigh stretchability (∼3000), a high ionic conductivity (up to 3.1 mS/cm), and a good temperature tolerance (-40 to 300 °C).
Journal ArticleDOI
A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion.
Xiaolei Huang,Lei-lei Tang,Lin Xu,Yu Zhang,Guan-xiong Li,Weiling Peng,Xiaolu Guo,Li Xing Zhou,Chanjuan Liu,Xing-Can Shen +9 more
TL;DR: These GG@PANI(Fe)-borax hydrogels may be used simultaneously for eradication of skin-tumor cells, inhibiting infection and accelerating wound healing, and offers an effective and facile strategy to fabricate an "all-in-one" multifunctional hydrogel platform for synergetic multimodal integrated therapy of tumors.
Journal ArticleDOI
Functionally multifaceted scaffolds delivering bioactive compounds for treatment of infectious chronic and ischemic wounds
TL;DR: In this article , a bilayer-type cryogel made up of chitosan-gelatin as base layer for housing the bioactive factors (nitric oxide nanoparticles as signaling molecule, cerium oxide microparticles as antioxidant, calcium peroxide microparticle as oxygen releasing moiety) has been fabricated using the Cryogelation method along with a top iodine embedded antibacterial layer.
References
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Journal ArticleDOI
Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing
TL;DR: These adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing and are an excellent wound dressing for full-thickness skin repair.
Journal ArticleDOI
Water absorption and states of water in semicrystalline poly(vinyl alcohol) films
TL;DR: In this paper, wide angle X-ray studies indicate that diffusion of water into semicrystalline samples of the polymer gradually destroys the crystalline regions of the polyvinyl alcohol, although water is found to not inhabit intact crystallites.
Journal ArticleDOI
Oral versus intravenous antibiotics for bone and joint infection
Li H-K.,Li H-K.,Ines Rombach,Rhea Zambellas,A S Walker,Martin A. McNally,B Atkins,Benjamin A. Lipsky,Harriet Hughes,D Bose,Michelle Kümin,C Scarborough,Philippa C Matthews,Andrew Brent,J Lomas,Roger Gundle,M Rogers,Adrian Taylor,Brian Angus,I. Byren,Anthony R. Berendt,S Warren,S Warren,F E Fitzgerald,Mack Djf.,Mack Djf.,Susan Hopkins,J Folb,Helen Reynolds,Elinoor Moore,John Marshall,N. Jenkins,C E Moran,A F Woodhouse,S Stafford,R.A. Seaton,C Vallance,C J Hemsley,K Bisnauthsing,Sandoe Jat.,I Aggarwal,S C Ellis,D J Bunn,R K Sutherland,Gavin Barlow,Cyrus Cooper,Claudia Geue,Nicola McMeekin,Andrew Briggs,Parham Sendi,E Khatamzas,Tri Wangrangsimakul,Wong Thn.,Lucinda Barrett,Abtin Alvand,C F Old,Jennifer Bostock,John Paul,Graham S Cooke,Guy E. Thwaites,Philip Bejon,Philip Bejon,M Scarborough,M Scarborough +63 more
TL;DR: Oral antibiotic therapy was noninferior to intravenous antibiotic therapy when used during the first 6 weeks for complex orthopedic infection, as assessed by treatment failure at 1 year after randomization.
Journal ArticleDOI
Physical Double-Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self-Healing, Antioxidant and NIR/pH Stimulus-Responsiveness for Multidrug-Resistant Bacterial Infection and Removable Wound Dressing
TL;DR: In vivo experiments prove that the hydrogels have good hemostasis of skin trauma and high killing ratio for methicillin‐resistant staphylococcus aureus and achieve better wound closure and healing of skin incision than medical glue and surgical suture.
Journal ArticleDOI
Gold‐Nanoshelled Microcapsules: A Theranostic Agent for Ultrasound Contrast Imaging and Photothermal Therapy
Hengte Ke,Jinrui Wang,Zhifei Dai,Yushen Jin,Enze Qu,Zhanwen Xing,Caixin Guo,Xiuli Yue,Jibin Liu +8 more
TL;DR: A novel multifunctional theranostic agent based on gold-nanoshelled microcapsules (GNS-MCs) is developed by electrostatic adsorption of gold nanoparticles as seeds onto the polymeric microcapsule surfaces, followed by the formation of gold nanoshells by using a surface seeding method.