Journal ArticleDOI
Thermosensitive sol-gel reversible hydrogels.
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TLDR
It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2002-01-17. It has received 2048 citations till now. The article focuses on the topics: Self-healing hydrogels & Drug delivery.read more
Citations
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†
TL;DR: This work highlights recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for biomedical and biological applications and shows how such systems' intelligent behavior can be used in sensors, microarrays, and imaging.
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
Patent
Surgical Stapling Apparatus
TL;DR: In this article, a surgical stapling device particularly suited for endoscopic procedures is described, which includes a handle assembly and an elongated body extending distally from the handle assembly.
Journal ArticleDOI
Hydrogels in controlled release formulations: network design and mathematical modeling
Chien-Chi Lin,Andrew T. Metters +1 more
TL;DR: The objective of this article is to review the fundamentals and recent advances in hydrogel network design as well as mathematical modeling approaches related to controlled molecule release from hydrogels.
References
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Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.
Journal ArticleDOI
Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association
TL;DR: In this article, a closed association model was used to describe the copolymer micellization process for the majority of the Pluronics and used to obtain the standard free energies, enthalpies, and entropies of micellisation.
Journal ArticleDOI
Poly(ethylene oxide)-poly(propylene oxide )-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling
TL;DR: In this article, the association properties of poly(ethylene oxide)-block-poly(propyleneoxide)-blockpoly(methylene oxide) (PEO) copolymers in aqueous solutions, and the adsorption at interfaces are reviewed.
Journal ArticleDOI
Novel injectable neutral solutions of chitosan form biodegradable gels in situ
Abdellatif Chenite,C Chaput,Dadong Wang,C Combes,Michael D. Buschmann,Caroline D. Hoemann,Jean-Christophe Leroux,B.L Atkinson,F Binette,A Selmani +9 more
TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.