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Book ChapterDOI

Thiopyrans and Their Benzo Derivatives

About: The article was published on 2020-01-01. It has received 1 citations till now. The article focuses on the topics: Ring (chemistry) & Section (typography).
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Journal ArticleDOI
TL;DR: An overview of the basic photophysics and electron transfer theory is presented in order to provide a comprehensive guide for employing this class of catalysts in photoredox manifolds.
Abstract: In this review, we highlight the use of organic photoredox catalysts in a myriad of synthetic transformations with a range of applications. This overview is arranged by catalyst class where the photophysics and electrochemical characteristics of each is discussed to underscore the differences and advantages to each type of single electron redox agent. We highlight both net reductive and oxidative as well as redox neutral transformations that can be accomplished using purely organic photoredox-active catalysts. An overview of the basic photophysics and electron transfer theory is presented in order to provide a comprehensive guide for employing this class of catalysts in photoredox manifolds.

3,550 citations

Journal ArticleDOI
TL;DR: This work focuses on the control of directional movement, both at the molecular scale and at larger magnitudes, and identifies some key challenges remaining in the field.
Abstract: Motor proteins are nature's solution for directing movement at the molecular level. The field of artificial molecular motors takes inspiration from these tiny but powerful machines. Although directional motion on the nanoscale performed by synthetic molecular machines is a relatively new development, significant advances have been made. In this review an overview is given of the principal designs of artificial molecular motors and their modes of operation. Although synthetic molecular motors have also found widespread application as (multistate) switches, we focus on the control of directional movement, both at the molecular scale and at larger magnitudes. We identify some key challenges remaining in the field.

591 citations

Journal ArticleDOI
TL;DR: The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies, and repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses.
Abstract: Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left with general supportive care and often untested convalescent-phase plasma as available treatment options. Repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to clinicians, researchers, public health agencies, drug developers, and funding agencies. Given the development times and manufacturing requirements for new products, repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses. In the studies described here, a library of 290 compounds was screened for antiviral activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). Selection of compounds for inclusion in the library was dependent on current or previous FDA approval or advanced clinical development. Some drugs that had a well-defined cellular pathway as target were included. In total, 27 compounds with activity against both MERS-CoV and SARS-CoV were identified. The compounds belong to 13 different classes of pharmaceuticals, including inhibitors of estrogen receptors used for cancer treatment and inhibitors of dopamine receptor used as antipsychotics. The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies.

581 citations

Journal ArticleDOI
TL;DR: Both compounds display efficient solid-state luminescence with an efficient up-conversion of the triplet to singlet and OLEDs based on them exhibt high performance up to 21.5%, which is among the best reported for OLEDs.
Abstract: H. Wang, L. Meng, Prof. Y. Wang, Prof. P. Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 , China E-mail: wangy@mail.ipc.ac.cn; wangpf@mail.ipc.ac.cn H. Wang, L. Meng University of Chinese Academy of Sciences Beijing 100049 , China Dr. Q. Peng, Prof. Y. Yi Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 , China L. Xie College of Life Science and Technology Beijing University of Chemical Technology Beijing , China

452 citations

Journal ArticleDOI
TL;DR: In this article, a review of recent progress in applications of photoinitiators and sensitive photo-initiating systems under visible lights is reported, and their relative efficiencies in the photopolymerization of different monomers are exemplified and discussed.

410 citations