Third Symposium on Parkinson's Disease
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This article is published in Journal of the Royal Society of Medicine.The article was published on 1970-05-01 and is currently open access. It has received 219 citations till now.read more
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Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.
Paul Krack,Alina Batir,Nadège Van Blercom,Stephan Chabardes,Valérie Fraix,Claire Ardouin,Adnan Koudsie,Patricia Limousin,Abdelhamid Benazzouz,Jean François LeBas,Alim-Louis Benabid,Pierre Pollak +11 more
TL;DR: There was no control group, but worsening of akinesia, speech, postural stability, freezing of gait, and cognitive function between the first and the fifth year is consistent with the natural history of Parkinson's disease.
Journal ArticleDOI
Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
TL;DR: This work clarifies the profile of cognitive dysfunction in early PD and demonstrates that the dementing process in this illness is heralded by both postural and gait dysfunction and cognitive deficits with a posterior cortical basis, reflecting probable non-dopaminergic cortical Lewy body pathology.
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The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
Caroline H. Williams-Gray,Jonathan R. Evans,An Goris,An Goris,Thomas Foltynie,Maria Ban,Trevor W. Robbins,Carol Brayne,Bhaskar Kolachana,Daniel R. Weinberger,Stephen Sawcer,Roger A. Barker +11 more
TL;DR: The work suggests that the dementing process in Parkinson's disease is predictable and related to tau while frontal-executive dysfunction evolves independently with a more dopaminergic basis and better prognosis.
Journal ArticleDOI
Influence of leisure activity on the incidence of Alzheimer's disease.
TL;DR: The data suggest that engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease.
Journal ArticleDOI
The effect of deprenyl (selegiline) on the natural history of Parkinson's disease
JW Tetrud,J. W. Langston +1 more
TL;DR: Early deprenyl therapy delays the requirement for antiparkinsonian medication, possibly by slowing progression of the disease.