Book ChapterDOI
Three or Four Heteroatoms including at least One Boron
M.V.R. Reddy,J.S. Chandra,Venkata Jaganmohan Reddy +2 more
- Vol. 6, pp 615-654
Reads0
Chats0
TLDR
In this paper, the authors describe various aspects of five-membered heterocyclic compounds containing one or more boron atoms, such as the procedures available for the preparation of these molecules, the reactivity of the heteroatoms (B, N, O, etc.) in the ring, the reactionivity of substituents attached to ring heterooms such as B−H, B−C, B-X, B·Si, B•Cu, etc.Abstract:
There has been an exponential increase in the synthesis and usage of a number of organic and inorganic boron compounds in the industry and academia. One of the important protocols for the synthesis of the organoboranes involves the hydroboration of olefins. This reaction is one of the most influential discoveries of the twentieth century in the field of organic synthesis. The organoboranes can be readily transformed into functional groups such as alcohols, amines, aldehydes, ketones, carboxylic acids, etc. The discovery of asymmetric versions of these reactions has added further impetus to the growing field of boron chemistry. This chapter describes various aspects of five-membered heterocyclic compounds containing one or more boron atoms, such as the procedures available for the preparation of these molecules, the reactivity of the heteroatoms (B, N, O, etc.) in the ring, the reactivity of substituents attached to ring heteroatoms such as B–H, B–C, B–X, B–Si, B–Cu, etc. The reactions have been categorized based on the reaction center; for example, the reactions of B–H, namely hydroboration of alkenes, asymmetric reduction of ketones, borylation and dehydrogenative borylation, etc., have been placed in a subcategory. Transition metal-catalyzed cross-couplings, stereoselective C–C bond-forming reactions such as allylation, Diels–Alder reaction, cycloadditions, and radical conjugate additions are among the key reactions that describe the reactivity of B–C bond. Several key transformations of B–X, B–Si, and B–Cu have also been dealt with in great detail. Apart from the reactivity, the ring syntheses from cyclic and acyclic compounds, and the syntheses of particular classes of compounds containing multiple heteroatoms have also been described in this chapter. Finally, some of the important compounds and their applications have been described at the end.read more
Citations
More filters
Journal ArticleDOI
Highly Diastereoselective Strain-Increase Allylborations: Rapid Access to Alkylidenecyclopropanes and Alkylidenecyclobutanes.
TL;DR: In this article, an α-cyclopropyl allylboronic ester was converted into a borinic ester, which gave alkylidenecyclopropanes in high yield.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998
TL;DR: The palladium-catalyzed cross-coupling reaction between organoboron compounds and organic halides or triflates provides a powerful and general methodology for the formation of carbon-carbon bonds as discussed by the authors.
Journal ArticleDOI
Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method.
E. J. Corey,Christopher J. Helal +1 more
TL;DR: High enantioselectivity can be achieved when chiral oxazaborolidines are used as catalysts in the reduction of ketones by borane when the two reactants are activated and held in close proximity by the catalyst.
Journal ArticleDOI
Efficient homogeneous catalysis in the reduction of CO2 to CO.
TL;DR: The use of a copper(I) alkoxide precatalyst and stoichiometric diboron reagent results in catalytic reduction of CO2, with high turnover numbers and frequencies depending on supporting ligand and reaction conditions.
Journal ArticleDOI
Palladium-catalyzed borylation of aryl halides or triflates with dialkoxyborane: A novel and facile synthetic route to arylboronates
TL;DR: A direct borylation of aryl halides or triflates with dialkoxyborane was investigated, and the tertiary amine, especially Et(3)N, was effective for the selective formation of the boron-carbon bond.