Journal ArticleDOI
Thresholds for carcinogens.
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TLDR
In this article, an integrated toxicological analysis is conducted to reconsider an alternative and once-promising approach, tumor latency, for estimating carcinogen-induced cancer risks at low doses.About:
This article is published in Chemico-Biological Interactions.The article was published on 2021-04-03. It has received 10 citations till now. The article focuses on the topics: Tumor initiation & Tumor promotion.read more
Citations
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Micro/nanoplastics effects on organisms: A review focusing on 'dose'.
TL;DR: In this article, a review of published literatures of microplastics effects on organisms within the context of "dose" is presented, which provides substantial evidence of the common occurrence of threshold and hormesis dose responses of numerous aquatic and terrestrial organisms to micro-plastics.
Journal ArticleDOI
Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
Olalekan Olanrewaju Bakare,Arun Gokul,Ruomou Wu,Lee-Ann Niekerk,Ashwil Klein,Marshall Keyster +5 more
TL;DR: In this paper, a review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use.
Journal ArticleDOI
Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia
TL;DR: Increasing evidence suggests that bacterial infection not only promotes carcinogenesis in primary colorectal cancer, but also affects metastatic progression and organ selectivity through modification of the microenvironment at primary and secondary tumor sites.
Journal ArticleDOI
Modeling of single cell cancer transformation using phase transition theory: application of the Avrami equation
TL;DR: In this paper, the authors used the Avrami equation to describe the nucleation and growth process of a single cell's DNA neoplastic transformation, which can enhance the multi-hit model of carcinogenesis to volumetric processes.
Journal ArticleDOI
In silico Prediction on the PI3K/AKT/mTOR Pathway of the Antiproliferative Effect of O. joconostle in Breast Cancer Models
Alejandra Ortiz-González,Pedro Pablo González-Pérez,M. Cárdenas-García,María Guadalupe Hernández-Linares +3 more
TL;DR: The in silico results show that, in a cancer cell, the activation of JAK and STAT, as well as PI3K and Akt is related to the effect of cell proliferation, angiogenesis, and inhibition of apoptosis, and that the extract of O. joconostle has an antiproliferative effect on breast cancer cells.
References
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Journal ArticleDOI
Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
R.J. Kociba,D.G. Keyes,J.E. Beyer,R.M. Carreon,C.E. Wade,D.A. Dittenber,R.P. Kalnins,L.E. Frauson,Colin N. Park,S.D. Barnard,R.A. Hummel,Charles G Humiston +11 more
TL;DR: It is indicated that continuous doses of TCDD sufficient to induce severe toxicity increased the incidence of some types of tumors, while reducing other types, and no increase in tumors occurred in those rats receiving sufficient TCDDs to induce slight or no manifestations of toxicity.
Journal ArticleDOI
Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
TL;DR: When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberration induced by [3 H]thcyidine and x-ray separately.
Journal ArticleDOI
Hormesis: why it is important to toxicology and toxicologists.
TL;DR: The article indicates that the hormetic dose response is the most fundamental dose response, significantly outcompeting other leading dose-response models in large-scale, head-to-head evaluations.
Journal ArticleDOI
Nrf2: friend or foe for chemoprevention?
TL;DR: This review provides a synopsis of KEAP1-NRF2 signaling, compares the impact of genetic versus pharmacologic activation and considers both the attributes and concerns of targeting the pathway in chemoprevention.
Book
Carcinogenesis by Ultraviolet Light
TL;DR: In this article, the authors tried to read carcinogenesis by ultraviolet light as one of the reading material to finish quickly and found that reading book can be a great choice when you have no friends and activities to accompany while in your lonely time.