Thrombolysis with Alteplase 3 to 4.5 Hours After Acute Ischemic Stroke
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...008).(169) However, mortality in the 2 treatment groups did not differ significantly and was nominally higher among the subjects treated with placebo....
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...However, mortality in the 2 treatment groups did not differ significantly and was nominally higher among the subjects treated with placebo.(169) The primary efficacy outcome in ECASS III was excellent 90-day outcome on the mRS global disability scale (mRS score 0–1)....
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...5 hours from symptom onset were randomized to either intravenous rtPA (n=418) or placebo (n=403).(169) The dosing regimen was 0....
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References
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...Stam (national coordinator); Norway (14): H....
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...Appendix The European Cooperative Acute Stroke Study (ECASS) investigators are as follows: Steering Committee — W. Hacke (chair), A. Dávalos, M. Kaste, R. von Kummer, V. Larrue, D. Toni, N. Wahlgren; Data and Safety Monitoring Board — K.R. Lees (chair), W.D. Heiss, E. Lesaffre, J.M. Orgogozo; Safety Outcome Adjudication Committee — R. von Kummer (chair), S. Bastianello, J.M. Wardlaw; Statisticians — J.-C. Peyrieux (STATMED, Lyon, France), C. Sauce (Boehringer Ingelheim); Trial Management Team at Boehringer Ingelheim — Z. Medeghri, R. Mazenc, C. Sauce, T. Machnig, E. Bluhmki; principal investigators (with the number of patients enrolled given in parentheses) — Austria (53): F. Aichner, C. Alf, U. Baumhackl, M. Brainin, C. Eggers, F. Gruber, G. Ladurner, K. Niederkorn, G. Noistering, J. Willeit; Belgium (22): G. Vanhooren (national coordinator), S. Blecic, B. Bruneel, J. Caekebeke, P. Laloux, P.J. Simons, V. Thijs; Czech Republic (18): M. Bar, H. Dvorakova, D. Vaclavik; Denmark (44): G. Boysen (national coordinator), G. Andersen, H.K. Iversen, B. Traberg-Kristensen; Finland (15): M. Kaste (national coordinator), R. Marttila, J. Sivenius; France (104): P. Trouillas (national coordinator), P. Amarenco, J. Bouillat, X. Ducrocq, M. Giroud, A. Jaillard, J.-M. Larrieu, V. Larrue, D. Leys, C. Magne, M.-H. Mahagne, D. Milhaud, D. Sablot, D. Saudeau; Germany (130): O. Busse (national coordinator), J. Berrouschot, J.H. Faiss, J. Glahn, M. Görtler, A. Grau, M. Grond, R. Haberl, G. Hamann, M. Hennerici, H. Koch, P. Krauseneck, J. Marx, S. Meves, U. Meyding-Lamadé, P. Ringleb, D. Schneider, A. Schwarz, J. Sobesky, P. Urban; Greece (2): K. Karageorgiou (national coordinator), A. Komnos; Hungary (9): A. Csányi, L. Csiba, A. Valikovics; Italy (147): D. Toni (national coordinator), G. Agnelli, G. Billo, P. Bovi, G. Comi, G. Gigli, D. Guidetti, D. Inzitari, N. Marcello, C. Marini, G. Orlandi, M. Pratesi, M. Rasura, A. Semplicini, C. Serrati, T. Tassinari; the Netherlands (5): P.J.A.M. Brouwers (national coordinator), J. Stam (national coordinator); Norway (14): H. Naess (national coordinator), B. Indredavik, R. Kloster; Poland (16): A. Czlonkowska (national coordinator), A. Kuczyńska-Zardzewialy, W. Nyka, G. Opala, S. Romanowicz; Portugal (13): L. Cunha (national coordinator), C. Correia, V. Cruz, T. Pinho e Melo; Slovakia (59): M. Brozman, M. Dvorak, R. Garay, G. Krastev, E. Kurca; Spain (111): J. Alvarez-Sabin (national coordinator), A. Chamorro, M. del Mar Freijo Guerrero, J.A.E. Herrero, A. Gil-Peralta, R. Leira, J.L. Martí-Vilalta, J. Masjuan Vallejo, M. Millán, C. Molina, E. Mostacero, T. Segura, J. Serena, J. Vivancos Mora; Sweden (14): E. Danielsson (national coordinator), B. Cederin, E. von Zweigberg, N.-G. Wahlgren, L. Welin; Switzerland (23): P. Lyrer (national coordinator), J. Bogousslavsky, H.-J. Hungerbühler, B. Weder; United Kingdom (22): G.A. Ford (national coordinator), D. Jenkinson, M.J. MacLeod, R.S. MacWalter, H.S. Markus, K.W. Muir, A.K. Sharma, M.R. Walters, E.A. Warburton....
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