Thymic myoid cells and myasthenia gravis.
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...Patients with LOMG (Fig....
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...In addition, the number of AIRE positive cells seems to decline as well, however, with no clear difference between LOMG thymuses and age matched controls....
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...The thymus exhibits pathological changes in the majority of patients with AChR antibodies (most patients with OMG, EOMG, LOMG and TAMG; Table 1), which seem to be of central importance for the impairment of central and peripheral tolerance and initiation of immunopathogenesis of MG (Figs....
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...Substantially increased export of naı̈ve T cells has not been observed in LOMG patients at the time of diagnosis [14, 85]....
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...Thymic myoid cells tend to be sparse in LOMG [90, 182], decline with age and can reach a state of near-deficiency between the age of 60 and 70 years, with considerable interpersonal variation [139]....
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