Time-dependent rates of molecular evolution.
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"Time-dependent rates of molecular e..." refers background in this paper
...In some studies, fast-evolving and poorly aligned sites are discarded to improve the ratio of phylogenetic signal to noise and to increase confidence in homology (Castresana 2000), leading to a biased representation of the sequence data....
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5,812 citations
5,209 citations
"Time-dependent rates of molecular e..." refers background in this paper
...In studies of sequences acquired from ancient samples, the DNA molecule can be altered by postmortem damage, the level of which is usually higher than typical sequencing error by an order of magnitude (Lindahl 1993)....
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3,297 citations
"Time-dependent rates of molecular e..." refers background in this paper
...The fate of neutral mutations in a population is determined solely by genetic drift and, unless there is strong linkage to sites under selection, the fixation rate depends only on the rate at which the mutations are generated (Kimura 1968)....
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...Indeed, when all mutations are strictly neutral, the long-term substitution rate is equal to the per generation, per individual mutation rate, regardless of population size (Kimura 1968)....
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2,850 citations
"Time-dependent rates of molecular e..." refers background in this paper
...Alternatively, some complexities in demographic history can be accommodated using flexible models of population change (e.g., Drummond et al. 2005; Heled & Drummond 2008)....
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