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Journal ArticleDOI

Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory.

15 Feb 2003-The Journal of Neuroscience (Society for Neuroscience)-Vol. 23, Iss: 4, pp 1517-1523
TL;DR: It is reported that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other, indicating that the time window of memory is a key factor in dissociating multiple memory systems.
Abstract: The prefrontal cortex and the dorsal hippocampus have been studied extensively for their significant roles in spatial working memory. A possible time-dependent functional relationship between the prefrontal cortex and the dorsal hippocampus in spatial working memory was tested. A combined lesion and pharmacological inactivation technique targeting both the dorsal hippocampus and the medial prefrontal cortex was used (i.e., axon-sparing lesions of the dorsal hippocampus combined with reversible inactivation of the medial prefrontal cortex, or vice versa, within a subject). A delayed nonmatching-to-place task on a radial eight-arm maze with short-term (i.e., 10 sec) versus intermediate-term (i.e., 5 min) delays was used as a behavioral paradigm. Here we report that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other. The role of the dorsal hippocampus, however, becomes highlighted as the time-window for memory (i.e., delay) shifts from short-term to a delay period (i.e., intermediate-term) exceeding the short-term range. The results indicate that the time window of memory is a key factor in dissociating multiple memory systems.
Citations
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Journal ArticleDOI
TL;DR: Advances in functional neuroimaging, neurophysiology, crossed-lesion neuropsychology and computational modelling highlight the importance of understanding how the medial temporal and frontal lobes interact to allow successful remembering, and provide an opportunity to explore these interactions.
Abstract: Cognitive neuroscience has made considerable progress in understanding the involvement of the medial temporal and frontal lobes in long-term memory. Whereas the medial temporal lobe has traditionally been associated with the encoding, storage and retrieval of long-term memories, the prefrontal cortex has been linked with cognitive control processes such as selection, engagement, monitoring and inhibition. However, there has been little attempt to understand how these regions might interact during encoding and retrieval, and little consideration of the anatomical connections between them. Recent advances in functional neuroimaging, neurophysiology, crossed-lesion neuropsychology and computational modelling highlight the importance of understanding how the medial temporal and frontal lobes interact to allow successful remembering, and provide an opportunity to explore these interactions.

918 citations


Cites background from "Time-dependent relationship between..."

  • ...For example, although both regions are involved in spatial memory, hippocampal involvement might be essential only when a sufficient delay is introduce...

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Journal ArticleDOI
TL;DR: It is suggested that the IL of rats is functionally homologous to the orbitomedial cortex of primates and the prelimbic cortex to the lateral/dorsolateral cortex of chimpanzees, and that theIL/PL complex of rats exerts significant control over emotional and cognitive aspects of goal-directed behavior.

744 citations

Journal ArticleDOI
TL;DR: An up-to-date computational theory of hippocampal function and the predictions it makes about the different subregions (dentate gyrus, CA3 and CA1) are presented, and behavioral and electrophysiological data that address the functions of the hippocampus and particularly its subregion are examined.

600 citations

Journal ArticleDOI
18 Jun 2015-Nature
TL;DR: It is found that direct hippocampal–prefrontal afferents are critical for encoding, but not for maintenance or retrieval, of spatial cues in mice, indicating a critical role for the direct hippocampusal– prefrontalAfferent pathway in the continuous updating of task-related spatial information during spatial working memory.
Abstract: Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of seconds, is a fundamental constituent of cognition Although the prefrontal cortex and hippocampus are known to contribute jointly to successful spatial working memory, the anatomical pathway and temporal window for the interaction of these structures critical to spatial working memory has not yet been established Here we find that direct hippocampal-prefrontal afferents are critical for encoding, but not for maintenance or retrieval, of spatial cues in mice These cues are represented by the activity of individual prefrontal units in a manner that is dependent on hippocampal input only during the cue-encoding phase of a spatial working memory task Successful encoding of these cues appears to be mediated by gamma-frequency synchrony between the two structures These findings indicate a critical role for the direct hippocampal-prefrontal afferent pathway in the continuous updating of task-related spatial information during spatial working memory

535 citations

Journal ArticleDOI
16 Feb 2006-Neuron
TL;DR: It is found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory.

514 citations


Cites background from "Time-dependent relationship between..."

  • ...In rats, both of these DNMTS tasks are dependent on an intact medial PFC (Floresco et al., 1997; Dias and Aggleton, 2000; Lee and Kesner, 2003)....

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References
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Book
01 Jan 1983
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Abstract: Preface. Acknowledgements. Introduction. References. List of Structures. Index of Abbreviations. Diagrams.

57,116 citations

Journal ArticleDOI
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
Abstract: In 1954 Scoville described a grave loss of recent memory which he had observed as a sequel to bilateral medial temporal-lobe resection in one psychotic patient and one patient with intractable seizures. In both cases the operations had been radical ones, undertaken only when more conservative forms of treatment had failed. The removals extended posteriorly along the mesial surface of the temporal lobes for a distance of approximately 8 cm. from the temporal tips and probably destroyed the anterior two-thirds of the hippocampus and hippocampal gyrus bilaterally, as well as the uncus and amygdala. The unexpected and persistent memory deficit which resulted seemed to us to merit further investigation. We have therefore carried out formal memory and intelligence testing of these two patients and also of eight other patients who had undergone similar, but less radical, bilateral medial temporallobe resections.* The present paper gives the results of these studies which point to the importance of the hippocampal complex for normal memory function. Whenever the hippocampus and hippocampal gyrus were damaged bilaterally in these operations some memory deficit was found, but not otherwise. We have chosen to report these findings in full, partly for their theoretical significance, and partly as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampal region.

7,041 citations


"Time-dependent relationship between..." refers background or methods in this paper

  • ...…that short-term memory is spared, whereas intermediate-term memory is relatively impaired with damage to the hippocampal system in both humans (Scoville and Milner, 1957; Eichenbaum et al., 1994; Holdstock et al., 1995; Eichenbaum, 2000; Kesner and Hopkins, 2001) and animals (Mishkin, 1978;…...

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  • ...Our prediction is that the dorsal hippocampus may play a more important role in intermediate-term memory compared with mPFC based on the previous literature (Scoville and Milner, 1957; Mishkin, 1978; Kesner and Novak, 1982; Kesner and Adelstein, 1989; Winocur, 1992; Jarrard, 1993; Alvarez et al., 1994; Eichenbaum et al., 1994; Holdstock et al., 1995; Steele and Morris, 1999; Eichenbaum, 2000; Porter et al., 2000; Clark et al., 2001; Fuster, 2001; Izaki et al., 2001; Kesner and Hopkins, 2001)....

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  • ...Therefore, it seems that the dorsal hippocampus and mPFC normally process short-term spatial working memory in parallel, which may explain the null effect of hippocampal damage on short-term or immediate memory in the previous literature (Scoville and Milner, 1957; Mishkin, 1978; Kesner and Novak, 1982; Kesner and Adelstein, 1989; Winocur, 1992; Jarrard, 1993; Alvarez et al., 1994; Eichenbaum et al., 1994; Holdstock et al., 1995; Steele and Morris, 1999; Eichenbaum, 2000; Porter et al., 2000; Clark et al., 2001; Kesner and Hopkins, 2001)....

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  • ...It is widely accepted that damage of the hippocampal system typically produces an episodic or spatial memory loss (Scoville and Milner, 1957; Jarrard, 1993; Eichenbaum, 2000)....

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  • ...…working memory in parallel, which may explain the null effect of hippocampal damage on short-term or immediate memory in the previous literature (Scoville and Milner, 1957; Mishkin, 1978; Kesner and Novak, 1982; Kesner and Adelstein, 1989; Winocur, 1992; Jarrard, 1993; Alvarez et al., 1994;…...

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Journal ArticleDOI
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.
Abstract: This article considers the role of the hippocampus in memory function. A central thesis is that work with rats, monkeys, and humans--which has sometimes seemed to proceed independently in 3 separate literatures--is now largely in agreement about the function of the hippocampus and related structures. A biological perspective is presented, which proposes multiple memory systems with different functions and distinct anatomical organizations. The hippocampus (together with anatomically related structures) is essential for a specific kind of memory, here termed declarative memory (similar terms include explicit and relational). Declarative memory is contrasted with a heterogeneous collection of nondeclarative (implicit) memory abilities that do not require the hippocampus (skills and habits, simple conditioning, and the phenomenon of priming). The hippocampus is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.

5,283 citations


"Time-dependent relationship between..." refers background in this paper

  • ...…systems in the brain, and the interaction between the hippocampal and neocortical systems has turned into a topic of importance in studying hippocampal function in memory (Mishkin and Appenzeller, 1987; Squire, 1992; Eichenbaum et al., 1994; Nadel, 1995; Eichenbaum, 2000; Maguire et al., 2000)....

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  • ...Memory appears to be the product of dynamic interactions among multiple systems in the brain, and the interaction between the hippocampal and neocortical systems has turned into a topic of importance in studying hippocampal function in memory (Mishkin and Appenzeller, 1987; Squire, 1992; Eichenbaum et al., 1994; Nadel, 1995; Eichenbaum, 2000; Maguire et al., 2000)....

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Journal ArticleDOI
TL;DR: Studies indicate that the prefrontal cortex is central in this process, providing an infrastructure for synthesizing a diverse range of information that lays the foundation for the complex forms of behaviour observed in primates.
Abstract: One of the enduring mysteries of brain function concerns the process of cognitive control. How does complex and seemingly willful behaviour emerge from interactions between millions of neurons? This has long been suspected to depend on the prefrontal cortex--the neocortex at the anterior end of the brain--but now we are beginning to uncover its neural basis. Nearly all intended behaviour is learned and so depends on a cognitive system that can acquire and implement the 'rules of the game' needed to achieve a given goal in a given situation. Studies indicate that the prefrontal cortex is central in this process. It provides an infrastructure for synthesizing a diverse range of information that lays the foundation for the complex forms of behaviour observed in primates.

1,786 citations


"Time-dependent relationship between..." refers background or result in this paper

  • ...Therefore, additional investigation is needed to determine whether the hippocampal–PFC interaction is critical primarily when proactively guidance and/or temporal integration of sequential responses are required (Seamans et al., 1995; Miller, 2000; Fuster, 2001)....

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  • ...Given the previously suggested executive and integrative role of PFC (Miller, 2000; Fuster, 2001; Tanji and Hoshi, 2001), our results suggest that PFC may have similar interactions with other brain regions [e.g., inferior temporal cortex (Fuster, 2001; Rolls and Deco, 2002)]....

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  • ...Given the previously suggested executive and integrative role of PFC ( Miller, 2000; Fuster, 2001; Tanji and Hoshi, 2001), our results suggest that PFC may have similar interactions with other brain regions [e.g., inferior temporal cortex (Fuster, 2001; Rolls and Deco, 2002)]....

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  • ...Therefore, additional investigation is needed to determine whether the hippocampal–PFC interaction is critical primarily when proactively guidance and/or temporal integration of sequential responses are required (Seamans et al., 1995; Miller, 2000; Fuster, 2001)....

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Journal ArticleDOI
01 May 2001-Neuron
TL;DR: The author states that the characters in this novel are based on real people who have lived and worked in the United States for many years and that their stories have changed over the years.

1,696 citations


"Time-dependent relationship between..." refers background or methods or result in this paper

  • ...…hippocampus or mPFC may take over the function of short-term spatial working memory when the other structure is unavailable, because previous literature suggests that both the PFC and the hippocampus are involved in spatial working memory with short-term delays (Hampson et al., 1999; Fuster, 2001)....

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  • ...However, the dorsal hippocampus or mPFC may take over the function of short-term spatial working memory when the other structure is unavailable, because previous literature suggests that both the PFC and the hippocampus are involved in spatial working memory with short-term delays (Hampson et al., 1999; Fuster, 2001)....

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  • ...Our prediction is that the dorsal hippocampus may play a more important role in intermediate-term memory compared with mPFC based on the previous literature (Scoville and Milner, 1957; Mishkin, 1978; Kesner and Novak, 1982; Kesner and Adelstein, 1989; Winocur, 1992; Jarrard, 1993; Alvarez et al., 1994; Eichenbaum et al., 1994; Holdstock et al., 1995; Steele and Morris, 1999; Eichenbaum, 2000; Porter et al., 2000; Clark et al., 2001; Fuster, 2001; Izaki et al., 2001; Kesner and Hopkins, 2001)....

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  • ...Because PFC is the brain region that has presumably the most dynamic and richest interactions with other brain regions, it is suggested that understanding the nature of PFC in the context of function of other brain regions is essential (Fuster, 2001)....

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  • ...…especially in a delayed matching- or nonmatching-to-sample task in which a correct choice response for a stimulus (e.g., object or spatial location) is required after a delay period (Delatour and Gisquet-Verrier, 1996; Floresco et al., 1997; Porter et al., 2000; Fuster, 2001; Izaki et al., 2001)....

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