Tin derived antimony/nitrogen-doped porous carbon (Sb/NPC) composite for electrochemical sensing of albumin from hepatocellular carcinoma patients
TL;DR: In this article, an antimony/nitrogen-doped porous carbon (Sb/NPC) composite was developed for the quantitative detection of albumin from hepatocellular carcinoma (HCC) patients.
Abstract: An electrochemical sensor based on an antimony/nitrogen-doped porous carbon (Sb/NPC) composite has been developed for the quantitative detection of albumin from hepatocellular carcinoma (HCC) patients. Sb/NPC is hydrothermally synthesized from Sn/NPC precursors. The synthesized precursor (Sn/NPC) and the product (Sb/NPC) are characterized by XRD, FTIR, TGA, UV/Vis, SEM, and AFM. Cyclic voltammetry, chronoamperometry, and electrochemical impedance studies are used to investigate the electrochemical performance of Sb/NPC-GCE. Sb/NPC-GCE detects albumin at physiological pH of 7.4 in the potential range 0.92 V and 0.09 V for oxidation and reduction, respectively. LOD and recovery of Sb/NPC-GCE for the determination of albumin are 0.13 ng.mL−1 and 66.6 ± 0.97–100 ± 2.73%, respectively. Chronoamperometry of the modified working electrode demonstrates its stability for 14 h, indicating its reusability and reproducibility. Sb/NPC-GCE is a selective sensor for albumin detection in the presence of interfering species. The electrode has been applied for albumin detection in human serum samples of HCC patients. A negative correlation of albumin with alpha-fetoprotein levels in HCC patients is observed by statistical analysis.
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TL;DR: In this article, a novel molecularly imprinted sensor was developed for the voltammetric determination of adrenaline (AD), which was used as a catalytic substrate for catalytic catalysts.
Abstract: A novel molecularly imprinted sensor was developed for the voltammetric determination of adrenaline (AD). MXene/carbon nanohorn (MXene/CNH) composite with good electric conductivity and enormous accessible active sites was firstly introduced as catalytic substrate. Subsequently, molecularly imprinted polymer (MIP) film was fabricated in mixed solutions containing hydroxymethyl-3,4-ethylenedioxythiophene (functional monomer) and AD (template) through electro-polymerization process. A molecularly imprinted sensor was formed after removing the template. The morphology and elemental composition of the prepared composites were studied by scanning electron microscopy and X-ray photoelectron spectroscopy. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were used to investigate the electrochemical performance of the molecularly imprinted sensors. Under optimized conditions, the designed sensor displays a wide linear range from 1.0 nM to 60.0 μM and a low limit of detection of 0.3 nM. The developed sensor also presents good selectivity, reproducibility and long-term stability, and satisfactory feasibility in practical sample analysis. MXene/carbon nanohorns decorated with conductive molecularly imprinted poly(hydroxymethyl-3,4-ethylenedioxythiophene) was proposed for highly sensitive and selective detection of adrenaline.
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TL;DR: In this paper , a biosensor for label-free detection of GPC3 was prepared by modifying GPC-3 aptamer (GPC3Apt) on the surface of Si-based light addressable potentiometric sensor (LAPS) chip modified by reduced graphene oxide/polyetherimide/gold nanoparticles (rGO/PEI/AuNPs).
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01 Jan 2003
TL;DR: The Optical Bloch Equations of a Two-Level Atom as mentioned in this paper are derived from a two-level atom and are used for light-matter interaction in light-matters interaction.
Abstract: Preface.PART I: LIGHT-MATTER INTERACTION: FUNDAMENTALS.Absorption and Emission of Radiation.Semiclassical Treatment of Absorption and Emission.The Optical Bloch Equations.Optical Bloch Equations of a Two-Level Atom.Quantized Fields and Dressed States.Forces from Atom-Light Interaction.The Laser.Elements of Optics.Index.
2,066 citations
TL;DR: This work presents a high-capacity supercapacitor material based on the nitrogen-doped porous carbon nan ofibers synthesized by carbonization of macroscopic-scale carbonaceous nanofibers coated with polypyrrole (CNFs@polypyr role) at an appropriate temperature.
Abstract: Supercapacitors (also known as ultracapacitors) are considered to be the most promising approach to meet the pressing requirements of energy storage. Supercapacitive electrode materials, which are closely related to the high-efficiency storage of energy, have provoked more interest. Herein, we present a high-capacity supercapacitor material based on the nitrogen-doped porous carbon nanofibers synthesized by carbonization of macroscopic-scale carbonaceous nanofibers (CNFs) coated with polypyrrole (CNFs@polypyrrole) at an appropriate temperature. The composite nanofibers exhibit a reversible specific capacitance of 202.0 F g–1 at the current density of 1.0 A g–1 in 6.0 mol L–1 aqueous KOH electrolyte, meanwhile maintaining a high-class capacitance retention capability and a maximum power density of 89.57 kW kg–1. This kind of nitrogen-doped carbon nanofiber represents an alternative promising candidate for an efficient electrode material for supercapacitors.
1,522 citations
TL;DR: In this article, Fourier transform infrared (FTIR) spectroscopy was carried out in the range of 400-4000 cm − 1 to study the attachment of the impurities on carbon nanotubes.
201 citations
TL;DR: In this article, a self-wrapping and controlled growth process with chitosan (CHI) as a self wrapping precursor is used for the fabrication of ultrasmall antimony (Sb) nanoparticles embedded in 3D nitrogen-doped porous carbon matrix.
138 citations
TL;DR: An overview of the state-of-the-art using albumin as drug carrier for specific accumulation in tumors and inflammatory cells using the advantageous properties of native albumin is given in this review.
Abstract: Importance in the field: Activated cells metabolize albumin to cover their increased need for amino acids and energy. In inflamed, diseased and malignant tissue, extravasation of macromolecules into the tissue is upregulated. Drug carriers such as albumin have been used to target specifically diseased and malignant cells, resulting in higher efficacy of treatment and reduced side effects.Areas covered in this review: Owing to its advantageous biochemical and pharmacological properties, albumin has been regarded as an interesting candidate as a drug carrier. Covalent coupling to albumin carries drugs specifically to tumors and sites of inflammation, leading to reduced side effects as long as the native structure of albumin is unchanged. In this review, the means of coupling drugs to native albumin as well as exemplary studies for the use of albumin as drug carrier are summarized and discussed.What the reader will gain: An overview of the state-of-the-art using albumin as drug carrier for specific accumulat...
131 citations