Journal ArticleDOI
Tissue Engineering of Skin
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TLDR
Tissue engineering (TE) and regenerative medicine area blend of developmental biology, life sciences, and engineering and lifesciences toward fundamental understanding of structure function relationships in normal and pathological mammalian tissues.Abstract:
Tissue engineering (TE) and regenerative medicine area blend of developmental biology, life sciences, and engi-neering efforts that attempts to address clinical problems.Tissue engineering was defined in 1988 as the applicationof principles and methods of engineering and lifesciences toward fundamental understanding of structurefunction relationships in normal and pathologicalmammalian tissues and the development of biologicsubstitutes to restore, maintain, or improve tissue func-tionread more
Citations
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Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review.
TL;DR: An overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented.
Journal ArticleDOI
Engineering Complex Tissues
TL;DR: This review highlights advances in tissue engineering technologies to enable regeneration of complex tissues and organs and to discuss how such innovative, engineered tissues can affect the clinic.
Journal ArticleDOI
Burn wound healing and treatment: review and advancements
Matthew P. Rowan,Leopoldo C. Cancio,Eric A. Elster,David M. Burmeister,Lloyd F. Rose,Shanmugasundaram Natesan,Rodney K. Chan,Robert J. Christy,Kevin K. Chung,Kevin K. Chung +9 more
TL;DR: Recent advancements in the care of burn patients with a focus on the pathophysiology and treatment of burn wounds are reviewed, including improvements in patient stabilization and care.
Journal ArticleDOI
Current development of biodegradable polymeric materials for biomedical applications
TL;DR: This review outlines the current development of biodegradable natural and synthetic polymeric materials for various biomedical applications, including tissue engineering, temporary implants, wound healing, and drug delivery.
Journal ArticleDOI
A review of three‐dimensional in vitro tissue models for drug discovery and transport studies
Nelita T. Elliott,Fan Yuan +1 more
TL;DR: This review provides an overview of some successful 3D in vitro models that have been developed to mimic liver, breast, cardiac, muscle, bone, and corneal tissues as well as malignant tissues in solid tumors.
References
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Journal ArticleDOI
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.
James G. Rheinwatd,Howard Green +1 more
TL;DR: Human diploid epidermis epidermal cells have been successfully grown in serial culture and it is possible to isolate keratinocyte clones free of viable fibroblasts, and human diploids keratinocytes appear to have a finite culture lifetime.
Journal ArticleDOI
Regulation of Wound Healing by Growth Factors and Cytokines
Sabine Werner,Richard Grose +1 more
TL;DR: This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
Journal ArticleDOI
Tissue Engineering--Current Challenges and Expanding Opportunities
Linda G. Griffith,Gail Naughton +1 more
TL;DR: In the future, engineered tissues could reduce the need for organ replacement, and could greatly accelerate the development of new drugs that may cure patients, eliminating theneed for organ transplants altogether.
Journal ArticleDOI
Capturing complex 3D tissue physiology in vitro.
TL;DR: Some of the 'design principles' for recreating the interwoven set of biochemical and mechanical cues in the cellular microenvironment are discussed, and the methods for implementing them are discussed.
Journal ArticleDOI
Defining the epithelial stem cell niche in skin.
Tudorita Tumbar,Géraldine Guasch,Valentina Greco,Cédric Blanpain,William E. Lowry,Michael Rendl,Elaine Fuchs +6 more
TL;DR: It is found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit, and their transcriptional profile is determined, which, when compared to progeny and other SCs, defines the niche.