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Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity

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TLDR
In this paper, obesity is associated with both insulin resistance and hyperinsulinemia, which is a condition that compensates for the insulin resistance by maintaining normal glucose homeostasis.
Abstract
Obesity is associated with both insulin resistance and hyperinsulinemia. Initially hyperinsulinemia compensates for the insulin resistance and thereby maintains normal glucose homeostasis. Obesity ...

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Journal ArticleDOI

Subcutaneous and visceral adipose tissue : Their relation to the metabolic syndrome

TL;DR: Methods for assessment of several phenotypes of human obesity, with special reference to abdominal fat content, have been evaluated and the endocrine regulation of abdominal visceral fat in comparison with the adipose tissue localized in other areas is presented.
Journal ArticleDOI

Adipose tissue as a buffer for daily lipid flux

Keith N. Frayn
- 24 Jul 2002 - 
TL;DR: The phenotype, at least with regard to insulin resistance, is similar with both excess and deficiency of adipose tissue, which could provide a framework for understanding the action of the thiazolidinedione insulin-sensitizing agents.
Journal ArticleDOI

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

TL;DR: In this article, it was shown that following an acute stimulus, particularly insulin or muscle contraction, specific fatty acid transporters translocate from intracellular stores to the plasma membrane to facilitate fatty acid uptake.
Journal ArticleDOI

Fatty acids, lipotoxicity and insulin secretion.

TL;DR: An auxiliary role of NEFA is to heighten the responsiveness of the pancreatic beta cell to a variety of insulin secretagogues, which can take on a pathophysiological dimension under certain circumstances.
Journal ArticleDOI

Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects

TL;DR: The notion that accumulation of IMCL-TG is a step in the development of FFA-induced insulin resistance was supported, taken together with previous reports of a close correlation between IM CL-TG and insulin resistance.
References
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Journal ArticleDOI

A simple method for the isolation and purification of total lipides from animal tissues.

TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
Journal ArticleDOI

Immunoassay of Endogenous Plasma Insulin in Man

TL;DR: For years investigators have sought an assay for insulin which would combine virtually absolute specificity with a high degree of sensitivity, sufficiently exquisite for measurement of the minute insulin concentrations usually present in the circulation as mentioned in this paper.
Journal ArticleDOI

Immunoassay of endogenous plasma insulin in man

TL;DR: The insulin concentration in plasma has been estimated from the degree of hypoglycemia produced in hypophysectomized, adrenalectomization, alloxan-diabetic rats, and from the increased oxidation of glucose-1-C14 by the rat epididymal fat pad.
Journal ArticleDOI

Effect of fatty acids on glucose production and utilization in man.

TL;DR: It is concluded that, in the well-insulinized state raised FFA levels effectively compete with glucose for uptake by peripheral tissues, regardless of the presence of hyperglycemia.
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