TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium
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3,249 citations
"TMBIM6 (transmembrane BAX inhibitor..." refers background in this paper
...Intracellular substrates are delivered to the lysosome by the autophagic pathway through the fusion of autophagosomes with lysosomes [8] and then degraded by a wide variety of hydrolases for recycling of cellular waste....
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2,409 citations
"TMBIM6 (transmembrane BAX inhibitor..." refers background in this paper
...TFEB is considered a master regulator of lysosomal and autophagic functions [3,4]....
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2,238 citations
"TMBIM6 (transmembrane BAX inhibitor..." refers methods in this paper
...Tissue samples for GFP observation were prepared as previously described [57,58]....
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1,967 citations
"TMBIM6 (transmembrane BAX inhibitor..." refers background or methods in this paper
...Tamotsu Yoshimori, Osaka University, Japan [35], and obtained from Addgene (21074)....
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...To confirm autophagosome and autolysosome formation, we performed tandem RFP-GFP-LC3 fluorescence analysis [35,36]....
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...RFP-GFP-LC3 plasmid encoding the tandem fluorescent reporter was generated in the laboratory of Dr. Tamotsu Yoshimori, Osaka University, Japan [35], and obtained from Addgene (21074)....
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1,928 citations
"TMBIM6 (transmembrane BAX inhibitor..." refers background in this paper
...TFEB is considered a master regulator of lysosomal and autophagic functions [3,4]....
[...]