Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model
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Cites background from "Tolerance and immunity to MUC1 in a..."
...…generally been ineffective in inducing humoral responses to the cancer-associated MUC1, when the mucin is expressed as a self-antigen, presumably because of tolerance (Goydos et al., 1996; Karanikas et al., 1997; Rowse et al., 1998; Adluri et al., 1999; Acres et al., 2000; Soares et al., 2001)....
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...These strategies have generally failed to produce effective immune responses to MUC1 expressed by cancer cells in hosts where the mucin is expressed as a self-antigen (Goydos et al., 1996; Karanikas et al., 1997; Rowse et al., 1998; Adluri et al., 1999; Acres et al., 2000; Gilewski et al., 2000; von Mensdorff-Pouilly et al., 2000a; Soares et al., 2001)....
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...MUC1 TR peptide vaccines have generally been ineffective in inducing humoral responses to the cancer-associated MUC1, when the mucin is expressed as a self-antigen, presumably because of tolerance (Goydos et al., 1996; Karanikas et al., 1997; Rowse et al., 1998; Adluri et al., 1999; Acres et al., 2000; Soares et al., 2001)....
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...…immune responses to MUC1 expressed by cancer cells in hosts where the mucin is expressed as a self-antigen (Goydos et al., 1996; Karanikas et al., 1997; Rowse et al., 1998; Adluri et al., 1999; Acres et al., 2000; Gilewski et al., 2000; von Mensdorff-Pouilly et al., 2000a; Soares et al., 2001)....
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...Tumor length (1) and width (2r) were determined at the indicated days postinjection....
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