Toll-like receptor signalling
Citations
10,685 citations
Cites background from "Toll-like receptor signalling"
...TLRs activate the same signaling molecules that are used for IL-1R signaling (Akira and Takeda, 2004)....
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...TLRs are evolutionarily conserved from the worm Caenorhabditis elegans to mammals (Akira and Takeda, 2004; Beutler, 2004; Hoffmann, 2003; Janeway and Medzhitov, 2002)....
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...TLRs as Pattern-Recognition Receptors TLRs are evolutionarily conserved from the worm Caenorhabditis elegans to mammals (Akira and Takeda, 2004; Beutler, 2004; Hoffmann, 2003; Janeway and Medzhitov, 2002)....
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5,915 citations
Cites background from "Toll-like receptor signalling"
...However, subsequent studies have demonstrated that individual TLR signaling pathways are divergent, and there are MyD88- dependent and MyD88-independent pathways (Akira and Takeda, 2004; Akira et al., 2006; Fig....
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...Once activated, IKKβ of the IKK complex induces phosphorylation and subsequent degradation of IκB, which leads to nuclear translocation of the transcription factor NFκB (Akira and Takeda, 2004)....
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3,947 citations
3,390 citations
Cites background from "Toll-like receptor signalling"
...PAMPs are pathogen byproducts, such as lipoproteins, bacterial DNA and double-stranded RNA, which are recognized by pattern recognition receptors (PRRs) found on a wide variety of cells, including fibroblasts [25]....
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3,338 citations
References
8,041 citations
"Toll-like receptor signalling" refers background in this paper
...However, recent studies have shown that the innate immune system has a greater degree of specificity than was previously thought and that it is highly developed in its ability to discriminate between self and foreign pathogen...
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