Toxic activities of the plant Jatropha curcas against intermediate snail hosts and larvae of schistosomes.
Melanie Rug,Andreas Ruppel +1 more
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TLDR
This study reports on the toxic activity of extracts from Jatropha curcas L. (Euphorbiaceae) against snails transmitting Schistosoma mansoni and S. mansoni, and suggests this plant could become an affordable and effective component of an integrated approach to schistosomiasis control.Abstract:
Summary The aim of studies on plant molluscicides is to complement methods for controlling snails acting as intermediate hosts of schistosomes. We report on the toxic activity of extracts from Jatropha curcas L. (Euphorbiaceae) against snails transmitting Schistosoma mansoni and S. haematobium. We studied different extracts' effects on infectious larvae, cercariae and miracidia of S. mansoni. Compared to aqueous extract, methanol extract showed the highest toxicity against all tested organisms with LC100-values of 25 p.p.m. for cercariae and the snail Biomphalaria glabrata and 1 p.p.m. for the snails Bulinus truncatus and B. natalensis. Attenuation of cercariae leading to reduced infectivity in mice could be achieved in concentrations below those exerting acute toxicity. In view of our results and the ongoing exploitation of J. curcas for other purposes, this plant could become an affordable and effective component of an integrated approach to schistosomiasis control.read more
Citations
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A concept for simultaneous wasteland reclamation, fuel production, and socio-economic development in degraded areas in India: need, potential and perspectives of Jatropha plantations.
TL;DR: The concept of substituting bio-diesel produced from plantations on eroded soils for conventional diesel fuel has gained wide-spread attention in India as discussed by the authors, where the Indian central Government as well as some state governments have expressed their support for bringing marginal lands, which cannot be used for food production, under cultivation for this purpose.
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Phorbol esters: structure, biological activity, and toxicity in animals.
TL;DR: The molluscicidal and insecticidal properties of phorbol esters indicate its potential to be used as an effective biopesticide and insecticide.
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Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems.
TL;DR: The effects of various phytochemicals and plant secondary metabolites in ruminant and fish species are discussed and some challenges and future areas of work in this field are presented.
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Jatropha curcas, a promising crop for the generation of biodiesel and value-added coproducts
TL;DR: In this paper, a review highlights the specific features of the Jatropha curcas plant and its potential for the production of biofuel, protein concentrates as livestock feed and value-added products that could enhance the economic viability of the plant in carbon capture, enhancing socioeconomic conditions, food production in the tropical regions and influencing microclimate, vegetation and soil quality.
References
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
TL;DR: Kinetic analysis indicates that TPA can substitute for diacylglycerol and greatly increases the affinity of the enzyme for Ca2+ as well as for phospholipid, and various phorbol derivatives which have been shown to be active in tumor promotion are also capable of activating this protein kinase in in vitro systems.
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The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.
S. R. Smithers,R. J. Terry +1 more
TL;DR: Smithers and Terry as discussed by the authors described techniques which are rapid and do not require great skill in their performance, and in their hands they have given very consistent results, in this respect they believe that these techniques have advantages over others which are currently practised.
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Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas
TL;DR: In this paper, 18 different provenances of Jatropha curcas from countries in West and East Africa, North and Central America, and Asia were characterized for nutrient and antinutritional factors.
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The biology and toxicology of molluscicides, bayluscide
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Irritant phorbol derivatives from four Jatropha species
TL;DR: Four Jatropha species used in folk medicine were screened for irritant constituents and highly irritant factors isolated from each species represent new polyunsaturated esters of the tigliane-type diterpenoids 16-hydroxyphorbol.