Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
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...Application of iron chelators is an established means of blocking Fenton reaction-mediated hydroxyl radical formation by sequestering unbound iron (Imlay et al., 1988)....
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...As expected (Imlay et al., 1988), we observed cellular death with 1 mM hydrogen peroxide (Figure 1A) accompanied by an increase in HPF fluorescence (Figure 1B)....
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...*Correspondence: jcollins@bu.edu DOI 10.1016/j.cell.2007.06.049...
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...…Advanced Biotechnology 2Department of Biomedical Engineering 3Program in Molecular Biology, Cell Biology, and Biochemistry 4Bioinformatics Program Boston University, Boston, MA 02215, USA 5Boston University School of Medicine, Boston, MA 02118, USA 6These authors contributed equally to this work....
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...The Fenton reaction leads to the formation of Cell 130, 797–810, September 7, 2007 ª2007 Elsevier Inc. 797 hydroxyl radicals through the reduction of hydrogen peroxide by ferrous iron (Imlay et al., 1988; Imlay and Linn, 1986)....
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