Open Access
Toxic effects of metals
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In this article, the effects of lead poisoning on the developing developing developing nervous system were investigated, including neurological, neurobehavioral, and developmental effects in children, and toxicity.Abstract:
Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics Metabolic Transformation Cellular Metabolism Toxicology Biological Indicators Treatment Nickel (Ni) Exposure Toxicokinetics Essentiality Toxicity Nickel Carbonyl Poisoning Dermatitis Indicators of Nickel Toxicityread more
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Book ChapterDOI
Heavy metal toxicity and the environment.
TL;DR: This review provides an analysis of arsenic, cadmium, chromium, lead, and mercury's environmental occurrence, production and use, potential for human exposure, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity.
Journal ArticleDOI
Oxidative mechanisms in the toxicity of metal ions
Sidney J. Stohs,Debasis Bagchi +1 more
TL;DR: Some mechanisms associated with the toxicities of metal ions are very similar to the effects produced by many organic xenobiotics, related to differences in solubilities, absorbability, transport, chemical reactions, and the complexes that are formed within the body.
Journal ArticleDOI
Reactive Oxygen Species, Oxidative Damage, and Antioxidative Defense Mechanism in Plants under Stressful Conditions
TL;DR: The generation, sites of production and role of ROS as messenger molecules as well as inducers of oxidative damage are described and the antioxidative defense mechanisms operating in the cells for scavenging of ROS overproduced under various stressful conditions of the environment are described.
Book
Heavy metals in soils : trace metals and metalloids in soils and their bioavailability
TL;DR: In this article, the authors defined the sources of heavy metals and metalloids in Soils and derived methods for the determination of Heavy Metals and Metalloids in soil.
Journal ArticleDOI
Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery
Patricia Horcajada,Christian Serre,Guillaume Maurin,Naseem A. Ramsahye,Francisco Balas,María Vallet-Regí,Muriel Sebban,Francis Taulelle,Gérard Férey +8 more
TL;DR: In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
References
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Journal ArticleDOI
Goodman and Gilman's the Pharmacological Basis of Therapeutics
William H. Stigelman,Pharm D. +1 more
Journal ArticleDOI
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
Jeremy M Berg,Yigong Shi +1 more
TL;DR: The ability of zinc to be bound specifically within a range of tetrahedral sites appears to be responsible for the evolution of the wide range of zinc-stabilized structural domains now known to exist.
Journal ArticleDOI
Methylmercury Poisoning in Iraq
F Bakir,S. F. Damluji,Laman Amin-Zaki,M. Murtadha,A. Khalidi,Naseer Al-Rawi,S. Tikriti,H. I. Dhahir,Thomas W. Clarkson,J.C. Smith,Richard A. Doherty +10 more
Journal ArticleDOI
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Rudolph E. Tanzi,Konstantin Petrukhin,Igor P. Chernov,Jean-Luc Pellequer,Wilma Wasco,B Ross,Donna M. Romano,Enrico Parano,Lorenzo Pavone,Linda M. Brzustowicz +9 more
TL;DR: The predicted functional properties of the pWD gene together with its strong homology to Mc1, genetic mapping data and identification of four independent disease–specific mutations, provide convincing evidence that pWD is the Wilson disease gene.
Journal ArticleDOI
High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men.
TL;DR: The data suggest that a high stored iron level, as assessed by elevated serum ferritin concentration, is a risk factor for coronary heart disease.