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Toxicological effects of some antiparasitic drugs on equine liver glutathione S-Transferase enzyme activity.
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TLDR
It was determined that RBZ, ALBA, OFZ are competitive inhibition, but TBZ is non-competitive inhibitors on glutathione s-transferase (GST) enzyme activity.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2020-02-20. It has received 5 citations till now. The article focuses on the topics: Oxfendazole.read more
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Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies
Cüneyt Türkeş,Arzu Öztürk Kesebir,Yeliz Demir,Ömer İrfan Küfrevioğlu,Şükrü Beydemir,Şükrü Beydemir +5 more
Journal ArticleDOI
When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms
TL;DR: In this article , the potential effects of environmental exposure to three classes of pharmaceutical drugs, i.e., antibiotics, antidepressants and non-steroidal anti-inflammatory drugs, on neurodevelopment are reviewed.
Journal ArticleDOI
Co and Zn Metal Phthalocyanines with Bulky Substituents: Anticancer, Antibacterial Activities and Their Inhibitory Effects on Some Metabolic Enzymes with Molecular Docking Studies
Fikret Türkan,Parham Taslimi,Beyza Cabir,Mehmet Salih Ağırtaş,Yavuz Erden,Hasan Ufuk Celebioglu,Burak Tüzün,Ercan Bursal,İlhami Gülçin +8 more
TL;DR: In this article, the synthesis of new cobalt and zinc phthalocyanine compounds with ((ethylenediamine-N,N, N’,N’-triacetic acid-N-2-ethyl)oxy) (ETAEO) substituted groups was reported.
Journal ArticleDOI
Synthesis, enzymes inhibitory properties and characterization of 2- (bis (4-aminophenyl) methyl) butan-1-ol compound: Quantum simulations, and in-silico molecular docking studies
Ümit Yildiko,Fikret Türkan,Aslihan Aycan Tanriverdi,Ahmet Cagri Ata,Mehmet Nuri Atalar,Ismail Cakmak +5 more
TL;DR: In this paper, the BAPMB molecule was synthesized and structurally characterized using the detailed DFT/B3LYP method with 6-311G (d, p) and SDD depended on the stable phase geometry of the molecule.
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New chalcone derivative, ethyl 2-(4-(3-(benzo[b]thiophen-2-yl)acryloyl)phenoxy)acetate: synthesis, characterization, DFT study, enzyme inhibition activities and docking study.
Fatih Çelik,Nevin Süleymanoğlu,Reşat Ustabaş,Fikret Türkan,Halil Ibrahim Guler,Yasemin Ünver,Nuran Kahriman +6 more
TL;DR: Chalcone derivative, ethyl 2-(4-(3-(benzo[b]thiophen-2yl)acryloyl)phenoxy)acetate (I), was synthesized as discussed by the authors.
References
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Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
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The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
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An Enzyme-Linked Immunoelectrotransfer Blot Assay and Glycoprotein Antigens for Diagnosing Human Cysticercosis (Taenia solium)
TL;DR: An enzyme-linked immunoelectrotransfer blot (EITB) assay was developed for immunodiagnosing human cysticercosis and identified seven major glycoprotein bands that are commonly recognized by virtually all serum and/or CSF samples from patients with confirmed cysticERCosis.
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Mode of action of benzimidazoles.
TL;DR: Ernest Lacey examines this example of selectivity of drug action to the ubiquitous target of these drugs, the structural protein, tubulin, and investigates why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.
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Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
TL;DR: In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity and a connection between antibacterial activity and electronic properties of the target compounds was determined.