Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
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...In vitro, the involvement of ROS and the subsequent activation of the transcription factor Nfr2 has also been shown in cultured keratinocytes [307]....
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...It should be noted that the gradient of H2O2 in cells is very steep, as evidenced by microscopic measurements in human keratinocytes (Pi et al., 2003) and mouse islets (Pi et al....
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...It should be noted that the gradient of H2O2 in cells is very steep, as evidenced by microscopic measurements in human keratinocytes (Pi et al., 2003) and mouse islets (Pi et al., 2007; Pi, 2009), so that all signaling by this molecule would require the target to be in very close proximity to the…...
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...Nrf2 activation by arsenic induced-cell damage has been reported in osteoblasts (Aono et al., 2003), human keratinocytes (Pi et al., 2003; Endo et al., 2008; Zhao et al., 2011), embryonic fibroblasts (He et al., 2006), human breast adenocarcinoma and human urothelial cells (Wang et al., 2008),…...
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...Aono et al. (2003) reported for the first time that inorganic arsenic activates the transcription factor Nrf2 and Pi et al. (2003) indicated that H2O2 is the mediator of arsenic-induced nuclear Nrf2 accumulation....
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