Transcription Factors in Long-Term Memory and Synaptic Plasticity

doi:10.1152/PHYSREV.00017.2008

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Transcription Factors in Long-Term Memory and Synaptic Plasticity

Journal Article•DOI•

Transcription Factors in Long-Term Memory and Synaptic Plasticity

Cristina M. Alberini¹•Institutions (1)

Icahn School of Medicine at Mount Sinai¹

01 Jan 2009-Physiological Reviews (American Physiological Society)-Vol. 89, Iss: 1, pp 121-145

TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.

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Abstract: Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview ...

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Journal Article•DOI•

Principles of Neural Science

[...]

Michael P. Alexander

06 Jun 1986-JAMA

TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.

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Abstract: I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

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7,563 citations

Journal Article•DOI•

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

[...]

Akinobu Suzuki¹, Sarah A. Stern¹, Ozlem Bozdagi¹, George W. Huntley¹, Ruth H. Walker¹, Pierre J. Magistretti², Cristina M. Alberini¹ - Show less +3 more•Institutions (2)

Icahn School of Medicine at Mount Sinai¹, École Polytechnique Fédérale de Lausanne²

04 Mar 2011-Cell

TL;DR: It is concluded that astrocyte-neuron lactate transport is required for long-term memory formation, suggesting that lactate import into neurons is necessary for long -term memory.

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1,255 citations

Cites background or methods from "Transcription Factors in Long-Term ..."

...The Critical Role of Astrocytes in Learning-Induced Molecular and Synaptic Changes We also found that pCREB and Arc expression, as well as pcofilin, which represent essential mechanisms underlying long-term synaptic plasticity and memory formation and their related synaptic structural changes (Alberini, 2009; Bramham et al., 2008) also depend on an intact glycogen metabolism and astrocyte-neuron lactate transport....
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...…as well as pcofilin, which represent essential mechanisms underlying long-term synaptic plasticity and memory formation and their related synaptic structural changes (Alberini, 2009; Bramham et al., 2008) also depend on an intact glycogen metabolism and astrocyte-neuron lactate transport....
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...Toward this end, we investigated the induction of Arc expression, ser 133 pCREB, which is known to be critical for CREB-dependent gene expression regulation (Alberini, 2009; Mayr and Montminy, 2001) and the phosphorylation of cofilin (pcofilin)....
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...Twenty hours after training was used to determine pCREB and pcofilin changes, since they are known to accompany the formation of long-term memory and plasticity for several hours or days (Alberini, 2009; Fedulov et al., 2007)....
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...Among the best characterized and widely proven gene expression mechanisms known to underlie memory consolidation are the activation of CREB (cAMP response element binding protein)-dependent gene expression (Alberini, 2009; Kandel, 2001) and the translation, at activated synapses, of the immediate early gene Arc (activity-regulated cytoskeletal protein), which is believed to play a key role in actin cytoskeletal dynamics and regulate themembrane expression of AMPA receptors (Bramham et al....
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Journal Article•DOI•

Molecular Mechanisms of Fear Learning and Memory

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Joshua P. Johansen¹, Christopher K. Cain¹, Christopher K. Cain², Linnaea E. Ostroff¹, Joseph E. LeDoux¹, Joseph E. LeDoux² - Show less +2 more•Institutions (2)

Center for Neural Science¹, Nathan Kline Institute for Psychiatric Research²

28 Oct 2011-Cell

TL;DR: This work discusses the neurotransmitter systems and signaling cascades that contribute to three phases of auditory fear conditioning: acquisition, consolidation, and reconsolidation and suggests that multiple intracellular signaling pathways interact to produce neural plasticity in the LA and behavioral fear conditioning.

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869 citations

Cites background from "Transcription Factors in Long-Term ..."

...that initiate gene transcription and translation of new proteins (Kandel, 2001; Bailey et al., 2000; Alberini, 2009; Hernandez and Abel, 2008)....
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...…plasticityinduced fear memory consolidation processes through PKAdependent cAMP response element binding protein (CREB) phosphorylation (which is also phosphorylated by Hebbian processes; see below) (see Alberini, 2009 for review) or activation of phosphatidylinositol-3 kinase (PI3-K; Figure 3)....
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...Once CREB is phosphorylated, it can, in combination with several cofactors, promote gene transcription of cAMP response element (CRE)-dependent genes (see Alberini, 2009, Deisseroth and Tsien, 2002, and Yin and Tully, 1996 for review)....
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...A major transcription factor implicated in memory formation in a variety of systems is CREB (for review, see Alberini, 2009)....
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...…consolidation of this plasticity is generally thought to occur via activation of second messengers 514 Cell 147, October 28, 2011 ª2011 Elsevier Inc. that initiate gene transcription and translation of new proteins (Kandel, 2001; Bailey et al., 2000; Alberini, 2009; Hernandez and Abel, 2008)....
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Journal Article•DOI•

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

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Saul A. Villeda¹, Kristopher E Plambeck², Jinte Middeldorp¹, Joseph M. Castellano¹, Kira I. Mosher¹, Jian Luo¹, Lucas K. Smith², Gregor Bieri¹, Karin Lin², Daniela Berdnik¹, Rafael Wabl¹, Joe C. Udeochu², Elizabeth G. Wheatley², Bende Zou, Danielle A. Simmons¹, Xinmin Xie, Frank M. Longo¹, Tony Wyss-Coray³ - Show less +14 more•Institutions (3)

Stanford University¹, University of California, San Francisco², VA Palo Alto Healthcare System³

01 Jun 2014-Nature Medicine

TL;DR: Exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function, and structural and cognitive enhancements elicited by exposure are mediated by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus.

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Abstract: As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Genome-wide microarray analysis of heterochronic parabionts--in which circulatory systems of young and aged animals are connected--identified synaptic plasticity-related transcriptional changes in the hippocampus of aged mice. Dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. At the cognitive level, systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory. Structural and cognitive enhancements elicited by exposure to young blood are mediated, in part, by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.

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823 citations

Patent•

Inhibitors of histone deacetylase

[...]

Oscar Moradei, Isabelle Paquin, Silvana Leit, Sylvie Frechette, Arkadii Vaisburg, Jeffrey M. Besterman, Pierre Tessier, Tammy C. Mallais - Show less +4 more

26 Oct 2007

TL;DR: In this article, the authors provide compounds and methods for inhibiting histone deacetylase enzymatic activity and also provide compositions for treating cell proliferative diseases and conditions.

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Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

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662 citations

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References

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Principles of Neural Science

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Eric R. Kandel, James H. Schwartz, Thomas M. Jessell

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Ian C. G. Weaver, Nadia Cervoni¹, Frances A. Champagne¹, Ana C. D'Alessio¹, Shakti Sharma, Jonathan R. Seckl², Sergiy Dymov¹, Moshe Szyf¹, Michael J. Meaney¹ - Show less +5 more•Institutions (2)

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Abstract: Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN) by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene promoter in the hippocampus. Offspring of mothers that showed high levels of LG and ABN were found to have differences in DNA methylation, as compared to offspring of 'low-LG-ABN' mothers. These differences emerged over the first week of life, were reversed with cross-fostering, persisted into adulthood and were associated with altered histone acetylation and transcription factor (NGFI-A) binding to the GR promoter. Central infusion of a histone deacetylase inhibitor removed the group differences in histone acetylation, DNA methylation, NGFI-A binding, GR expression and hypothalamic-pituitary-adrenal (HPA) responses to stress, suggesting a causal relation among epigenomic state, GR expression and the maternal effect on stress responses in the offspring. Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible.

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5,514 citations

"Transcription Factors in Long-Term ..." refers background in this paper

...Thus the epigenomic state of a gene can be established through behavioral programming and is potentially reversible (245)....
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Journal Article•DOI•

Shared principles in NF-kappaB signaling

[...]

Matthew S. Hayden¹, Sankar Ghosh¹•Institutions (1)

Yale University¹

08 Feb 2008-Cell

TL;DR: The authors synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aim to generate a more unified view of the regulation of the transcription factor.

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3,996 citations

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Memory--a century of consolidation.

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James L. McGaugh¹•Institutions (1)

University of California, Irvine¹

14 Jan 2000-Science

TL;DR: This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories.

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Abstract: The memory consolidation hypothesis proposed 100 years ago by Muller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.

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3,902 citations