Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages Insights into the Phagosomal Environment
Citations
1,254 citations
919 citations
Cites background from "Transcriptional Adaptation of Mycob..."
...tuberculosis in activated macrophages from inducible nitric oxide synthase knockout (NOS2 / ) mice (13)....
[...]
...2 C were highly expressed in mouse lung 21 d after infection and showed, in addition, that they remained expressed at high levels 56 d after infection (13)....
[...]
692 citations
663 citations
Cites background from "Transcriptional Adaptation of Mycob..."
...5)P2] and PI(3,4,5)P3 participate in phagocytic cup formation and enclosure, probably in synergy with the SNAREs, VAMP3, and VAMP7, otherwise associated with recycling endosomes or exocytosis, respectively....
[...]
...tuberculosis has demonstrated that Mycobacteria regulate a myriad of genes to secure a sufficient supply of iron within the cell, whereas macrophages aim to restrict the availability of this metal by different mechanisms (5)....
[...]
...The PIs phosphatidyl inositol (4,5)-biphosphate [PI(4....
[...]
659 citations
References
12,102 citations
Additional excerpts
...cance analysis of microarrays program (14)....
[...]
...These results and those from the six to seven amplicon microarrays were analyzed by the significance analysis of microarrays program using a false discovery rate of 1% (14)....
[...]
7,779 citations
"Transcriptional Adaptation of Mycob..." refers background or result in this paper
...Several genes in cluster VI are predicted by their annotated functions (28) to be involved in lipid metabolism, whereas most genes in clusters IV and V encode proteins of unknown function....
[...]
...Taken together, these data support the view that MTB uses fatty acids as a carbon source during in vivo growth (21, 28, 45)....
[...]
2,774 citations
"Transcriptional Adaptation of Mycob..." refers background in this paper
...Through a variety of cell surface receptors, macrophages internalize microbes into phagosomes that undergo maturational events that expose the microbes to acid, lytic enzymes, oxygenated lipids, fatty acids, and reactive oxygen and nitrogen intermediates (1, 2)....
[...]
2,080 citations
1,498 citations
"Transcriptional Adaptation of Mycob..." refers background in this paper
...Despite this battery of antimicrobial molecules, some pathogens are able to survive and replicate within macrophage phagosomes (3, 4)....
[...]
...The mechanisms that allow some pathogens to survive within phagosomes include inhibition of phagosomal maturation, resistance against antimicrobial molecules, and adaptation to host-induced metabolic constraints (3)....
[...]