Transcriptional regulation by the phosphorylation-dependent factor CREB
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...domain, which is consistent with the findings that these factors can form both homo- and heterodimers, and that each can bind to the same cis-regulatory element (reviewed in De Cesare et al., 1999; Mayr and Montminy, 2001; Shaywitz and Greenberg, 1999)....
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1,401 citations
Cites background from "Transcriptional regulation by the p..."
...CREB is well known as a target of mitogenic signaling pathways (137)....
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...Although CREB sites are common to cAMP- and growthactivated genes (137), these elements are not a general feature of nuclear respiratory promoters....
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1,373 citations
1,255 citations
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...Toward this end, we investigated the induction of Arc expression, ser 133 pCREB, which is known to be critical for CREB-dependent gene expression regulation (Alberini, 2009; Mayr and Montminy, 2001) and the phosphorylation of cofilin (pcofilin)....
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1,238 citations
References
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"Transcriptional regulation by the p..." refers background in this paper
...Induction of cAMP liberates the C subunits, which passively diffuse into the nucleus and induce cellular gene expression by phosphorylating CREB at serine residue 133 (Ref...
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2,041 citations
1,944 citations
"Transcriptional regulation by the p..." refers background in this paper
...A role for CREB in growth-factor-dependent survival has been shown in sympathetic and cerebellar neuron...
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1,832 citations
"Transcriptional regulation by the p..." refers background in this paper
...Disruption of the α- and δ-isoforms of CREB in mice, for example, leads to defects in long-term potentiation and long-term memor...
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1,471 citations
"Transcriptional regulation by the p..." refers background in this paper
...Phosphorylation of Ser133 potentiates activity of the KID by promoting recruitment of the co-activator paralogues CBP and p300 to the promote...
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