Transcriptional Regulatory Networks in Saccharomyces cerevisiae
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Cites background or methods from "Transcriptional Regulatory Networks..."
...The simplest units of commonly used transcriptional regulatory network architecture, or network motifs, provide specific regulatory capacities such as positive and negative feedback loops to control the levels of their components (Lee et al., 2002; Milo et al., 2002; Shen-Orr et al., 2002)....
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...Studies in a broad range of eukaryotes have shown that transcriptional regulators that have key roles in cellular processes frequently regulate other regulators associated with that process (Guenther et al., 2005; Lee et al., 2002; Odom et al., 2004)....
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...Previous studies have shown that feedforward-loop architecture has been highly favored during the evolution of transcriptional regulatory networks in less complex eukaryotes (Lee et al., 2002; Ma et al., 2004; Milo et al., 2002; Resendis-Antonio et al., 2005; Shen-Orr et al., 2002)....
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...Previous studies have shown that feedforwardloop architecture has been highly favored during the evolution of transcriptional regulatory networks in less complex eukaryotes (Lee et al., 2002; Ma et al., 2004; Milo et al., 2002; Resendis-Antonio et al., 2005; Shen-Orr et al., 2002)....
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...In order to identify regulatory network motifs associated with OCT4, SOX2, and NANOG, we assumed that regulator binding to a gene implies regulatory control and used algorithms that were previously devised to discover such regulatory circuits in yeast (Lee et al., 2002)....
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