Journal ArticleDOI
Transcriptional repression shapes the identity and function of tissue macrophages
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TLDR
In this paper, the authors focus on transcriptional repressors that play roles in tissue macrophage development and function under physiological conditions, including metabolic syndromes, immune-deficiencies, and tumor development.About:
This article is published in FEBS Open Bio.The article was published on 2021-08-14. It has received 5 citations till now. The article focuses on the topics: Innate immune system.read more
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The complex role of tumor-infiltrating macrophages
Anthos Christofides,Laura Strauss,Alan Tien Yeo,C. Cao,Alain Charest,Vassiliki A. Boussiotis +5 more
TL;DR: The hallmarks of TAMs are outlined and the emerging mechanisms that contribute to their pathophysiological adaptations and the vulnerabilities that provide attractive targets for therapeutic exploitation in cancer are discussed.
Journal ArticleDOI
Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy
Xiao-Ling Ding,Xinchen Sun,Huihui Cai,Lei Wu,Ying Liu,Yu Zhao,Di Zhou,Gui-Hua Yu,Xiaorong Zhou +8 more
TL;DR: Several new directions in macrophage engineering are reviewed, such as transporting NP drugs throughmacrophage cell membranes or extracellular vesicles, reprogramming tumor-associated macrophages (TAMs) by nanotechnology, and engineering Macrophages with CARs.
Journal ArticleDOI
HIV Latency in Myeloid Cells: Challenges for a Cure
TL;DR: Resting memory CD4+ T cells are summarized in this review for their importance when designing HIV cure strategies and challenges associated to their identification and specific targeting by the “shock and kill” approach.
Journal ArticleDOI
Ten years of FEBS Open Bio.
TL;DR: The FEBS Open Bio Journal celebrated its 10th birthday in 2010 as mentioned in this paper and published a special anniversary issue, comprised of editorials, reviews, and research articles especially commissioned for the occasion.
References
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Journal ArticleDOI
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Suhas S.P. Rao,Miriam H. Huntley,Neva C. Durand,Elena K. Stamenova,Ivan D. Bochkov,James T. Robinson,James T. Robinson,Adrian L. Sanborn,Ido Machol,Ido Machol,Arina D. Omer,Arina D. Omer,Eric S. Lander,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden +15 more
TL;DR: In situ Hi-C is used to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types, identifying ∼10,000 loops that frequently link promoters and enhancers, correlate with gene activation, and show conservation across cell types and species.
Journal ArticleDOI
An nrf2/small maf heterodimer mediates the induction of phase ii detoxifying enzyme genes through antioxidant response elements
Ken Itoh,Tomoki Chiba,Satoru Takahashi,Tetsuro Ishii,Kazuhiko Igarashi,Yasutake Katoh,Tatsuya Oyake,Norio Hayashi,Kimihiko Satoh,Ichiro Hatayama,Masayuki Yamamoto,Yo-ichi Nabeshima +11 more
TL;DR: It is demonstrated that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes and the nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs.
Journal ArticleDOI
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte,David A. Orlando,Denes Hnisz,Brian J. Abraham,Charles Y. Lin,Charles Y. Lin,Michael H. Kagey,Peter B. Rahl,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: In this article, the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state, called super-enhancers, which consist of clusters of enhancers that are densely occupied by the master regulators and Mediator.
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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Leo E. Otterbein,Leo E. Otterbein,Fritz H. Bach,Jawed Alam,Miguel P. Soares,Hong-Tao Lu,Mark Allen Wysk,Roger J. Davis,Richard A. Flavell,Augustine M.K. Choi,Augustine M.K. Choi +10 more
TL;DR: It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Cheng-Ming Sun,Jason A. Hall,Jason A. Hall,Rebecca Blank,Nicolas Bouladoux,Mohamed Oukka,J. Rodrigo Mora,Yasmine Belkaid +7 more
TL;DR: It is shown that peripheral conversion of CD4+ T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) after oral exposure to antigen and in a lymphopenic environment, and that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.