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Journal ArticleDOI

Transformations of N‐heteroarylformamidines into derivatives of β‐heteroarylamino‐α,β‐dehydro‐α‐amino acids, β‐heteroarylamino‐α‐amino acids, and dipeptides

01 Nov 1987-Journal of Heterocyclic Chemistry (Wiley)-Vol. 24, Iss: 6, pp 1809-1810
TL;DR: In this article, a general method for the preparation of β-heteroarylamino-α, β-dehydro-α-amino acids and dipeptides is described.
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 1987-11-01. It has received 26 citations till now. The article focuses on the topics: Carboxamide & Dipeptide.
Citations
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Journal ArticleDOI
TL;DR: Methyl 2-benzoylamino-3-dimethylaminopropenoate (2) was introduced as a new reagent for the preparartion of fused pyrimidinones 4 from heterocyclic α-amino compounds in acetic acid as mentioned in this paper.

25 citations

Journal ArticleDOI
TL;DR: The β-heteroarylaminomethyleneoxazolones as mentioned in this paper were obtained from heterogeneous formamidines and obtained by catalytic hydrogenation the compounds were converted into βhetero-arylamino substituted amides.

24 citations

References
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Journal ArticleDOI
TL;DR: The formamide acetals as mentioned in this paper have been used in two main categories of reactions, namely alkylation and formylation, and are used in the synthesis of esters from acids, ethers and thioethers from phenols and aromatic and heterocyclic thiols.

233 citations

Journal ArticleDOI
TL;DR: Pharmacological and clinical studies on ACE inhibitors of novel chemical structure will establish their utility as antihypertensive agents and may lead to greater understanding of the mechanism of action of all ACE inhibitors.
Abstract: A decade of experimentation, with work in the last four years greatly accelerated by the availability of captopril, favors the conclusion that angiotensin-converting enzyme inhibitors exert their antihypertensive effect by blocking the formation of angiotensin II. The apparently anomalous efficacy of ACE inhibitors in hypertension characterized by low circulating renin levels may point to the importance of the vascular renin-angiotensin system in controlling blood pressure. Neither kinin potentiation nor blockade of the CNS renin-angiotensin system appear to play a significant role in the antihypertensive effect of captopril. Pharmacological and clinical studies on ACE inhibitors of novel chemical structure will establish their utility as antihypertensive agents and may lead to greater understanding of the mechanism of action of all ACE inhibitors.

186 citations

Journal ArticleDOI
TL;DR: In this paper, alle wesentlichen Beitrage und Anderungen zur Kenntnis uber das naturliche Vorkommen von Aminosauren zusammenfassend darzustellen.
Abstract: Mit Hilfe moderner Trennungsmethoden sind in den letzten 15 Jahren zahlreiche neue Aminosauren entdeckt worden. Es wird versucht, alle wesentlichen Beitrage und Anderungen zur Kenntnis uber das naturliche Vorkommen von Aminosauren zusammenfassend darzustellen. Die Chemie und Biochemie der neuen Verbindungen sowie ihre Isolierung und Konstitutionsermittlung werden erlautert.

76 citations

Journal ArticleDOI
TL;DR: In this paper, selective methylation of some compounds containing both SH and NH groups was performed to give first the S-methyl and subsequently the S,N-dimethyl derivatives.
Abstract: Methylations of heterocyclic systems, such as benzimidazole, naphth[2,3-c]imidazole, imidazo[4,5-c]-pyridine, purine, pyridine, pyrimidine, pyridazine and s-triazolo[4,3-b]pyridazine, which bore SH, NH and/or OH groups, were carried out with dimethylformamide dimethyl acetal to give the corresponding S-, N- and/or O-methyl derivatives in high yields. Selective methylation of some compounds containing both SH and NH groups took place to give first the S-methyl and subsequently the S,N-dimethyl derivatives. No side reactions, such as C-methylation, were observed.

49 citations