Journal ArticleDOI
Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
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TLDR
In patients with significant gastrointestinal haemorrhage, the use of a transfusion trigger of a haemoglobin level of 7 g/dL instead of 9g/dL demonstrated a significant survival benefit (NNT 25) together with a significant reduction in rates of rebleeding, adverse events and use of blood products.Abstract:
In patients with significant gastrointestinal haemorrhage, the use of a transfusion trigger of a haemoglobin level of 7 g/dL instead of 9 g/dL demonstrated a significant survival benefit (NNT 25) together with a significant reduction in rates of rebleeding, adverse events and use of blood products.Level of evidence: 2B (non-blind, single centre RCT with a risk of bias)read more
Citations
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Journal ArticleDOI
Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage
Jeffrey L. Carson,Gordon H. Guyatt,Nancy M. Heddle,Brenda J. Grossman,Claudia S. Cohn,Mark K. Fung,Terry Gernsheimer,John B. Holcomb,Lewis J. Kaplan,Louis M. Katz,Nikki Peterson,Glenn Ramsey,Sunil V. Rao,John D. Roback,Aryeh Shander,Aaron A.R. Tobian +15 more
TL;DR: A restrictive RBC transfusion threshold is safe in most clinical settings and the current blood banking practices of using standard-issue blood should be continued.
Journal ArticleDOI
Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Ian M. Gralnek,Ian M. Gralnek,Jean-Marc Dumonceau,Ernst J. Kuipers,Angel Lanas,David S Sanders,Matthew Kurien,Gianluca Rotondano,Tomas Hucl,Mário Dinis-Ribeiro,Riccardo Marmo,I. Racz,Alberto Arezzo,Ralf Thorsten Hoffmann,Gilles Lesur,Roberto de Franchis,Lars Aabakken,Andrew Veitch,Franco Radaelli,Paulo Salgueiro,Ricardo S. Cardoso,Luís Maia,Angelo Zullo,Livio Cipolletta,Cesare Hassan +24 more
TL;DR: This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy and addresses the diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH).
Journal ArticleDOI
European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases
Axel Dignass,Christoph Gasche,Dominik Bettenworth,Gunnar Birgegård,Silvio Danese,Javier P. Gisbert,Fernando Gomollón,Tariq Iqbal,Konstantinos Katsanos,Ioannis E. Koutroubakis,Fernando Magro,Guillaume Savoye,Jürgen Stein,Stephan R. Vavricka +13 more
TL;DR: European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases is presented.
Journal ArticleDOI
Management of cardiogenic shock
TL;DR: This updated review will outline the management of CS complicating acute myocardial infarction with major focus on evidence-based revascularization techniques, intensive care unit treatment including ventilation, transfusion regimens, adjunctive medication, and mechanical support devices.
Journal ArticleDOI
Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference
Markus M. Mueller,Hans Van Remoortel,Patrick Meybohm,Kari Aranko,Cecile Aubron,Reinhard Burger,Jeffrey L. Carson,Klaus Cichutek,Emmy De Buck,Dana V. Devine,Dean Fergusson,G. Folléa,Craig French,Kathrine P. Frey,Richard Gammon,Jerrold H. Levy,Michael F. Murphy,Yves Ozier,Katerina Pavenski,Cynthia So-Osman,Pierre Tiberghien,Jimmy Volmink,Jonathan H. Waters,Erica M. Wood,Erhard Seifried +24 more
TL;DR: The relative paucity of strong evidence to answer many of the PICO questions supports the need for additional research and an international consensus for accepted definitions and hemoglobin thresholds, as well as clinically meaningful end points for multicenter trials.
References
More filters
Journal ArticleDOI
Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage
Jeffrey L. Carson,Gordon H. Guyatt,Nancy M. Heddle,Brenda J. Grossman,Claudia S. Cohn,Mark K. Fung,Terry Gernsheimer,John B. Holcomb,Lewis J. Kaplan,Louis M. Katz,Nikki Peterson,Glenn Ramsey,Sunil V. Rao,John D. Roback,Aryeh Shander,Aaron A.R. Tobian +15 more
TL;DR: A restrictive RBC transfusion threshold is safe in most clinical settings and the current blood banking practices of using standard-issue blood should be continued.
Journal ArticleDOI
Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Ian M. Gralnek,Ian M. Gralnek,Jean-Marc Dumonceau,Ernst J. Kuipers,Angel Lanas,David S Sanders,Matthew Kurien,Gianluca Rotondano,Tomas Hucl,Mário Dinis-Ribeiro,Riccardo Marmo,I. Racz,Alberto Arezzo,Ralf Thorsten Hoffmann,Gilles Lesur,Roberto de Franchis,Lars Aabakken,Andrew Veitch,Franco Radaelli,Paulo Salgueiro,Ricardo S. Cardoso,Luís Maia,Angelo Zullo,Livio Cipolletta,Cesare Hassan +24 more
TL;DR: This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy and addresses the diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH).
Journal ArticleDOI
European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases
Axel Dignass,Christoph Gasche,Dominik Bettenworth,Gunnar Birgegård,Silvio Danese,Javier P. Gisbert,Fernando Gomollón,Tariq Iqbal,Konstantinos Katsanos,Ioannis E. Koutroubakis,Fernando Magro,Guillaume Savoye,Jürgen Stein,Stephan R. Vavricka +13 more
TL;DR: European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases is presented.
Journal ArticleDOI
Management of cardiogenic shock
TL;DR: This updated review will outline the management of CS complicating acute myocardial infarction with major focus on evidence-based revascularization techniques, intensive care unit treatment including ventilation, transfusion regimens, adjunctive medication, and mechanical support devices.
Journal ArticleDOI
Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference
Markus M. Mueller,Hans Van Remoortel,Patrick Meybohm,Kari Aranko,Cecile Aubron,Reinhard Burger,Jeffrey L. Carson,Klaus Cichutek,Emmy De Buck,Dana V. Devine,Dean Fergusson,G. Folléa,Craig French,Kathrine P. Frey,Richard Gammon,Jerrold H. Levy,Michael F. Murphy,Yves Ozier,Katerina Pavenski,Cynthia So-Osman,Pierre Tiberghien,Jimmy Volmink,Jonathan H. Waters,Erica M. Wood,Erhard Seifried +24 more
TL;DR: The relative paucity of strong evidence to answer many of the PICO questions supports the need for additional research and an international consensus for accepted definitions and hemoglobin thresholds, as well as clinically meaningful end points for multicenter trials.