Journal ArticleDOI
Transient receptor potential channels as therapeutic targets
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TLDR
This Review focuses on recent developments in the TRP channel-related field, and highlights potential opportunities for therapeutic intervention.Abstract:
Transient receptor potential (TRP) cation channels have been among the most aggressively pursued drug targets over the past few years. Although the initial focus of research was on TRP channels that are expressed by nociceptors, there has been an upsurge in the amount of research that implicates TRP channels in other areas of physiology and pathophysiology, including the skin, bladder and pulmonary systems. In addition, mutations in genes encoding TRP channels are the cause of several inherited diseases that affect a variety of systems including the renal, skeletal and nervous system. This Review focuses on recent developments in the TRP channel-related field, and highlights potential opportunities for therapeutic intervention.read more
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TRP Channels and Pain
TL;DR: Analysis of TRP channel function and expression has validated the existence of nociceptors as a specialized group of somatosensory neurons devoted to the detection of noxious stimuli and is providing insight into the coding logic of nnociception and how specification of nOCiceptor subtypes underlies behavioral discrimination ofNoxious thermal, chemical, and mechanical stimuli.
Journal ArticleDOI
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
TL;DR: An overview of DAMP-sensing receptors is provided, the crosstalk between these receptors is discussed, and the cross-regulation of these receptors and their ligands are discussed.
Journal ArticleDOI
Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
TL;DR: Research on the pathological mechanisms of neuroaxonal dysfunction and injury, such as altered ion channel activity, and the endogenous neuroprotective pathways that counteract oxidative stress and mitochondrial dysfunction are reviewed to identify potential novel therapeutic targets in MS.
Journal ArticleDOI
Ion Channels in Innate and Adaptive Immunity
TL;DR: The mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells are reviewed and their roles in lymphocyte development, adaptive and innateimmune responses, and autoimmunity are discussed, as well as recent efforts to develop pharmacological inhibitors of ions for immunomodulatory therapy.
Journal ArticleDOI
Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine
Bernd Nilius,Arpad Szallasi +1 more
TL;DR: An overview of the functional properties of mammalian TRP channels is given, their roles in acquired and hereditary diseases are described, and their potential as drug targets for therapeutic intervention is discussed.
References
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Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
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TRP channels as cellular sensors
TL;DR: TRP channels are the vanguard of the authors' sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli, but their role is much broader than classical sensory transduction.
Journal ArticleDOI
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Gina M. Story,Andrea M. Peier,Alison J. Reeve,Samer R. Eid,Johannes Mosbacher,Todd R. Hricik,Taryn J. Earley,Anne C. Hergarden,David Andersson,Sun Wook Hwang,Peter McIntyre,Timothy Jegla,Stuart Bevan,Ardem Patapoutian,Ardem Patapoutian +14 more
TL;DR: The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8.
Journal ArticleDOI
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Surya M. Nauli,Francis J. Alenghat,Ying Luo,Eric O. Williams,Peter M. Vassilev,Xiaogang Li,Andrew E. H. Elia,Weining Lu,Edward M. Brown,Stephen J. Quinn,Donald E. Ingber,Jing Zhou +11 more
TL;DR: PC1 and PC2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both function in the same mechanotransduction pathway, suggesting loss or dysfunction of PC1 or PC2 may lead to polycystic kidney disease.