Translational Application of Microfluidics and Bioprinting for Stem Cell-Based Cartilage Repair
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"Translational Application of Microf..." refers background in this paper
...Indeed, microfluidic technology enables the precise control over fluids at the microscale, thus allowing mimicking of the natural cell microenvironment by continuous perfusion culture or by creating chemical gradients [14]....
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5,375 citations
"Translational Application of Microf..." refers background in this paper
...Autologous chondrocyte implantation (ACI) has been the first cell-based approach to treat cartilage defects [2, 3], and more lately, stem cells have been proposed as an alternative cell source for cell-based cartilage repair [4, 5]....
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2,339 citations
"Translational Application of Microf..." refers background in this paper
...Furthermore, microfluidic devices can be used to develop organotypic models of the whole articular joint capable to recapitulate either a physiological or a pathological environment [81], perfectly matching the concept of organs-on-chips for the study of tissue development, organ physiology, and disease etiology [82, 83]....
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2,298 citations
"Translational Application of Microf..." refers background in this paper
...Furthermore, hydrogels can be easily tailored in different geometries and, if properly designed, can provide the cells with an environment similar to that of native cartilage [36, 37]....
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2,082 citations
"Translational Application of Microf..." refers background in this paper
...Indeed, the controlled perfusion of the culture medium within microchannels allows maintaining more uniform culture conditions than standard static approaches, providing the stable supply of nutrients and growth factors as well as the removal of waste products [13, 53]....
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...In this scenario, microfluidic systems have attracted significant interest implementing platforms, in which the control of local environmental conditions, including biochemical and biophysical parameters, is exploited to study and direct stem cell fate [12, 13]....
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