Journal ArticleDOI
Transplacental pharmacokinetics and teratogenicity of a single dose of retinol (vitamin A) during organogenesis in the mouse.
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TLDR
The concentration-time profile of retinoids after 100 mg/kg on day 11 showed a pronounced increase of retinyl esters and retinol in all compartments including the embryo and a massive generation of the polar metabolites all-trans-retinoic acid and all- trans-4-oxoretinoic acids, both well-known teratogens.About:
This article is published in Toxicology Letters.The article was published on 1989-08-01. It has received 52 citations till now. The article focuses on the topics: Retinol & Vitamin.read more
Citations
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Journal ArticleDOI
Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern.
TL;DR: The relationship between chemical structure and toxicity was explored through the compilation of a large reference database consisting of over 600 chemical substances tested for a variety of endpoints resulting in over 2900 no-observed-effect levels (NOELs), supporting the contention that chemical structure defines toxicity.
Book ChapterDOI
Retinoic Acid: Its Biosynthesis and Metabolism
TL;DR: The discussion details the evidence supporting an integrated model of retinoid-binding protein/metabolism and evidence incompatible with ethanol causing fetal alcohol syndrome by competing directly with retinol dehydrogenation to impair retinoic acid biosynthesis.
Journal ArticleDOI
Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.
Christian Eckhoff,Heinz Nau +1 more
TL;DR: The findings suggest that, in addition to all-trans-retinoic acid, 13-cis-retinosic acid and 13- cis-4-oxoretinoic Acid are present in normal human plasma as metabolites of vitamin A.
Journal ArticleDOI
4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse.
TL;DR: The data suggest that the teratogenic activity of a single high dose of vitamin A in mouse is partially but not exclusively dependent on the metabolic activation of retinol to all -trans retinoic acid.
Journal ArticleDOI
Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo.
TL;DR: The spatially closely related but non-overlapping domains of expression of CRBP I and CRABP I suggests a role of a retinol/RA pathway in epithelial-mesenchymal interactions during pattern formation of limbs and of craniofacial structures.
References
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Journal ArticleDOI
Identification of a receptor for the morphogen retinoic acid.
TL;DR: Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors and Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
Journal ArticleDOI
A Note on the Staining of the Skeleton of Cleared Specimens with Alizarin Red S
TL;DR: A selective, progressive method for staining the skeleton in cleared specimens, developed with rat material, depends on obtaining the proper degree of clearing before staining.
Journal ArticleDOI
Identification and spatial distribution of retinoids in the developing chick limb bud.
Christina Thaller,Gregor Eichele +1 more
TL;DR: It is reported that chick limb buds contain endogenous RA and it is shown that RA, but not its biosynthetic precursor retinol, forms a concentration gradient across the limb anlage with a high-point in the posterior domain of the limb bud, the part that also contains the ZPA.
Journal ArticleDOI
Excessive Intake of Vitamin A as a Cause of Congenital Anomalies in the Rat
Journal ArticleDOI
The biosynthesis of retinoic acid from retinol by rat tissues in vitro
Joseph L. Napoli,Kevin R. Race +1 more
TL;DR: It is shown that a spectrum of vitamin A-dependent tissues can produce retinoic acid by synthesis in situ, and it is indicated that cellular retinol and retinoIC acid binding proteins are not obligatory to retinoing acid synthesis, and initial characterization of retinoi acid synthesis by rat tissues is provided.
Related Papers (5)
Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.
Christian Eckhoff,Heinz Nau +1 more