Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers
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...Although the extracellular segment of ErbB2 lacks a tether nd occurs in an extended conformation, ErbB2 does not form ctive dimers unless it is overexpressed [22]....
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...However, unphysiological overexpression f ErbB2 leads to the formation of a functional homodimer [22]....
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"Trastuzumab Has Preferential Activi..." refers background in this paper
...or eventually progress after therapy with trastuzumab (14, 44), thus suggesting the presence of de novo and acquired mechanisms of drug resistance....
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"Trastuzumab Has Preferential Activi..." refers background in this paper
...ErbB receptors are transmembrane tyrosine kinases comprising four members: ErbB1/EGFR, ErbB2/HER2, ErbB3/ HER3, and ErbB4/HER4 (1)....
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"Trastuzumab Has Preferential Activi..." refers background or methods in this paper
...liferation, reduction in apoptosis of centrally located cells, disruption of tight junctions and polarity, and induction of acinar expansion without invasion into surrounding matrix (23, 32)....
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...Three-dimensional Matrigel growth assay About 5 10(3) cells/well were seeded in 8-well chamber slides in DMEM/F-12 medium supplemented with cholera toxin, hydrocortisone, insulin and 2% HS on growth factor– reduced Matrigel (BD Biosciences), as described (23)....
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