Book ChapterDOI
Traumatic brain injury.
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TLDR
In childhood, traumatic brain injury poses the unique challenges of an injury to a developing brain and the dynamic pattern of recovery over time, so the treatment needs to be multifaceted and starts at the scene of the injury and extends into the home and school.Abstract:
In childhood, traumatic brain injury (TBI) poses the unique challenges of an injury to a developing brain and the dynamic pattern of recovery over time, inflicted TBI and its medicolegal ramifications. The mechanisms of injury vary with age, as do the mechanisms that lead to the primary brain injury. As it is common, and is the leading cause of death and disability in the USA and Canada, prevention is the key, and we may need increased legislation to facilitate this. Despite its prevalence, there is an almost urgent need for research to help guide the optimal management and improve outcomes. Indeed, contrary to common belief, children with severe TBI have a worse outcome and many of the consequences present in teenage years or later. The treatment needs, therefore, to be multifaceted and starts at the scene of the injury and extends into the home and school. In order to do this, the care needs to be multidisciplinary from specialists with a specific interest in TBI and to involve the family, and will often span many decades.read more
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Journal ArticleDOI
Network hubs in the human brain
TL;DR: Combining data from numerous empirical and computational studies, network approaches strongly suggest that brain hubs play important roles in information integration underpinning numerous aspects of complex cognitive function.
Journal ArticleDOI
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Andrew I R Maas,David K. Menon,P. David Adelson,Nada Andelic,Michael J. Bell,Antonio Belli,Peter Bragge,Alexandra Brazinova,Andras Buki,Randall M. Chesnut,Giuseppe Citerio,Mark Coburn,D. Jamie Cooper,A Tamara Crowder,Endre Czeiter,Marek Czosnyka,Ramon Diaz-Arrastia,Jens P. Dreier,Ann-Christine Duhaime,Ari Ercole,Thomas A. van Essen,Valery L. Feigin,Guoyi Gao,Joseph T. Giacino,Laura E. Gonzalez-Lara,Russell L. Gruen,Russell L. Gruen,Deepak Gupta,Jed A. Hartings,Sean Hill,Jiyao Jiang,Naomi Ketharanathan,Erwin J. O. Kompanje,Linda Lanyon,Steven Laureys,Fiona Lecky,Harvey S. Levin,Hester F. Lingsma,Marc Maegele,Marek Majdan,Geoffrey T. Manley,Jill A. Marsteller,Luciana Mascia,Charles McFadyen,Stefania Mondello,Virginia F. J. Newcombe,Aarno Palotie,Aarno Palotie,Aarno Palotie,Paul M. Parizel,Wilco C. Peul,James Piercy,Suzanne Polinder,Louis Puybasset,Todd E. Rasmussen,Rolf Rossaint,Peter Smielewski,Jeannette Söderberg,Simon J. Stanworth,Murray B. Stein,Nicole von Steinbüchel,William Stewart,Ewout W. Steyerberg,Ewout W. Steyerberg,Nino Stocchetti,Anneliese Synnot,Anneliese Synnot,Braden Te Ao,Olli Tenovuo,Alice Theadom,Dick Tibboel,Walter Videtta,Kevin K.W. Wang,W. Huw Williams,Lindsay Wilson,Kristine Yaffe,Hadie Adams,Vanni Agnoletti,Judith Allanson,Krisztina Amrein,Norberto Andaluz,Audny Anke,Anna Antoni,Arjan Bastiaan van As,Gérard Audibert,Antun Azaševac,Philippe Azouvi,Maria Luisa Azzolini,Camelia Baciu,Rafael Badenes,Karen M. Barlow,Ronald H. M. A. Bartels,Ursula Bauerfeind,Miriam H. Beauchamp,Darcy Beer,Ronny Beer,Francisco Javier Belda,Bo-Michael Bellander,Rémy Bellier,Habib Benali,Thierry Benard,Valzerda Beqiri,Luigi Beretta,Francis Bernard,Guido Bertolini,Federico Bilotta,Morten Blaabjerg,Hugo den Boogert,Kathy Boutis,Pierre Bouzat,Brian L. Brooks,Camilla Brorsson,Monika Bullinger,Emma Burns,Calappi E,Peter Cameron,Elsa Carise,Ana M. Castaño-Leon,Francesco Causin,Giorgio Chevallard,Arturo Chieregato,Brian R. Christie,Maryse C. Cnossen,Jonathan P. Coles,Johnny Collett,Francesco Della Corte,William Craig,Gábor Csató,Ákos Csomós,Nicola Curry,Claire Dahyot-Fizelier,Helen Dawes,Carol DeMatteo,Bart Depreitere,Deborah Dewey,Jeroen T. J. M. van Dijck,Đula Đilvesi,Diederik W.J. Dippel,Kemal Dizdarevic,Emma Donoghue,Or Duek,Guy-Loup Dulière,Adelaida Dzeko,George A. Eapen,Carolyn A. Emery,Shane W. English,Patrick Esser,Erzsébet Ezer,Martin Fabricius,Junfeng Feng,Dean Fergusson,Anthony Figaji,Joanne Fleming,Kelly A Foks,G. Francony,Stephen B. Freedman,Ulderico Freo,Shirin Frisvold,Isabelle Gagnon,Damien Galanaud,Dashiell Gantner,Benoit Giraud,Ben Glocker,Jagos Golubovic,Pedro A Gómez López,Wayne A. Gordon,Primoz Gradisek,Jocelyn Gravel,Donald E. G. Griesdale,Francesca Grossi,Juanita A. Haagsma,Asta Håberg,Iain K. Haitsma,Wim Van Hecke,Raimund Helbok,Eirik Helseth,Caroline M. van Heugten,Cornelia W. E. Hoedemaekers,Stefan Höfer,Lindsay Horton,Jiyuan Hui,Jilske A Huijben,Peter J. Hutchinson,Bram Jacobs,Mathieu van der Jagt,Stefan Jankowski,Koen Janssens,Bojan Jelaca,Kelly Jones,Konstantinos Kamnitsas,Rafael Kaps,Mladen Karan,Ari Katila,Kirsi-Maija Kaukonen,Véronique De Keyser,Riku Kivisaari,Angelos G. Kolias,Balint Kolumban,Ksenija Kolundžija,Daniel Kondziella,Lars-Owe D. Koskinen,Noémi Kovács,Andreas H. Kramer,Demitri Kutsogiannis,Theodoros Kyprianou,Alfonso Lagares,Francois Lamontagne,Roberto Latini,François Lauzier,Isaac Lazar,Christian Ledig,Rolf Lefering,Valerie Legrand,Leon Levi,Roger Lightfoot,Angels Lozano,Stephen MacDonald,Sebastian Major,Alex Manara,Pauline Manhes,Hugues Maréchal,Costanza Martino,Alessandro Masala,Serge Masson,Julia Mattern,Bradford J. McFadyen,Catherine McMahon,Maureen O. Meade,Béla Melegh,Tomas Menovsky,Lynne Moore,Marta M Correia,Maria Cristina Morganti-Kossmann,Holger Muehlan,Pratik Mukherjee,Lynnette Murray,Joukje van der Naalt,Ancuta Negru,David W. Nelson,Daan Nieboer,Quentin Noirhomme,József Nyirádi,Mauro Oddo,David O. 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Takala,Päivi Tanskanen,Mark Taylor,Ralph Telgmann,Nancy R. Temkin,Guido Teodorani,Matthew Thomas,Christos M. Tolias,Tony Trapani,Alexis F. Turgeon,Peter Vajkoczy,Alex B. Valadka,Egils Valeinis,Shirley Vallance,Zoltan Vamos,Alessia Vargiolu,Emmanuel Vega,Jan Verheyden,Anne Vik,Rimantas Vilcinis,Carmen L.A. Vleggeert-Lankamp,Lidia Vogt,Victor Volovici,Daphne C. Voormolen,Peter Vulekovic,Thijs Vande Vyvere,Julia Van Waesberghe,Lars Wessels,Eno Wildschut,Guy B. Williams,Maren K.L. Winkler,Stefan Wolf,Gordon Wood,Nektaria Xirouchaki,Alexander Younsi,Menashe Zaaroor,Veronika Zelinkova,Roger Zemek,Fabrizio Zumbo +342 more
TL;DR: The InTBIR Participants and Investigators have provided informed consent for the study to take place in Poland.
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Incidence of traumatic brain injury in New Zealand: a population-based study
Valery L. Feigin,Alice Theadom,Suzanne Barker-Collo,Nicola J. Starkey,Kathryn M. McPherson,Michael Kahan,Anthony Dowell,Paul Brown,Varsha Parag,Robert R. Kydd,Kelly Jones,Amy Jones,Shanthi Ameratunga +12 more
TL;DR: The findings suggest that the incidence of TBI, especially mild TBI with age-specific and residency-specific data for TBI incidence overall and by mechanism of injury should be considered when planning prevention and TBI care services.
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TL;DR: The key to developing future anti-inflammatory based neuroprotective treatments for TBI is to minimize the detrimental and neurotoxic effects of neuroinflammation while promoting the beneficial and neurotrophic effects, thereby creating optimal conditions for regeneration and repair after injury.
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Neurofilament light chain as a biomarker in neurological disorders
Lorenzo Gaetani,Kaj Blennow,Paolo Calabresi,Massimiliano Di Filippo,Lucilla Parnetti,Henrik Zetterberg +5 more
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